Dyslipidemia, Obesity, Overweight
Conditions
Keywords
Opuntia ficus-indica, dyslipidemia, overweight, obesity, diet
Brief summary
Background: Opuntia ficus-indica is a plant from the cactus family (Cactaceae) that is widespread and of great economic importance in Mexico. It has been consumed as food since pre-Hispanic times and is currently considered a nutraceutical. In this study, the effect of consumption of dehydrated nopal powder from highly mature cladodes (Opuntia ficus-indica) on the lipid profile of overweight or obese patients diagnosed with dyslipidemia was investigated. Methods: A 3-month prospective clinical trial was conducted in 35 overweight or obese patients with dyslipidemia. The sample was divided into three groups with a daily intake of 30 g of dietary fiber: Group I received 5 g of dehydrated Opuntia ficus-indica cladodes plus the standard normocaloric diet for dyslipidemia, Group II received 15 g plus the diet, and Group III followed only the diet.
Interventions
DIETARY_SUPPLEMENTsupplementation with 5 g dehydrated nopal powder from highly mature cladodes
Group I received 5 g of dehydrated Opuntia ficus-indica cladodes plus the standard normocaloric diet for dyslipidemia.
DIETARY_SUPPLEMENTsupplementation with 15 g dehydrated nopal powder from highly mature cladodes
Group II received 15 g plus the diet, and Group III followed only the diet.
OTHERControl Group (only diet)
No dehydrated nopal or placebo. Diet: 30 g of fiber per day Normocaloric diet Carbohydrates 55%, Lipids 25% and Proteins 20%
Sponsors
Universidad Autónoma de Querétaro
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Group I (first arm): 5 g of dehydrated nopal + normocaloric diet. Group II (second arm): 15 g of dehydrated nopal + normocaloric diet. Group III (third arm): normocaloric diet only (control or comparison group). This design allows for the comparison of the effects of different doses or treatments (in this case, different amounts of nopal) against a control (the diet alone).
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Participants with dyslipidemia, confirmed by lipid meas-urement in blood chemistry * overweight or obesity * A cardiovascular risk factor associated with abdominal obesity
Exclusion criteria
* Patients with a suspected diagnosis of primary dyslipidemia * Diabetes * Hypertension * Thyroid disease were excluded from the study * Patients with complex or severe disease such as heart failure, liver or kidney disease * Pregnant or lactating women * Indidividuals taking lipid-modifying drugs or hormone replacement therapy - Patients with gastrointestinal problems and deficiencies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood lipid levels | From enrollment to the end of treatment at 12 weeks | A blood sample (3 ml) was taken from the patients after fasting for 12 hours, then prepared for subsequent analysis by an enzymatic method. The Clinical 50 VWR cen-trifuge ® was used for sample preparation and the Roche Cobas C 111 ® kit for lipid analysis of the samples. These analyses were performed in duplicate. Comparison of supplementation with dehydrated nopal powder from highly mature cladodes, by group, in initial and final values of the lipid profile: Total cholesterol; LDL, Low-density lipoproteins; HDL, High-density lipoproteins; TGL, Tri-glycerides. |
Countries
Mexico
Outcome results
None listed