CMR-derived Quantitative Perfusion for Prediction of FFR

Quantification of Myocardial Blood Flow in Cardiovascular Magnetic Resonance for Prediction of Fractional Flow Reserve in Coronary Catheterisation

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07018778

Enrollment

200

Registered

2025-06-12

Start date

2025-07-01

Completion date

2026-09-30

Last updated

2025-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Coronary Syndrome

Brief summary

Patients will undergo quantitative perfusion assessment in cardiovascular magnetic resonance imaging (dual bolus or dual sequence approach) as well as invasive coronary angiography for assessment of fractional flow reserve (FFR) including assessment of coronary flow reserve (CFR) and microcirculatory resistance (IMR).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Inclusion criteria

* clinical indication for vasodilatator CMR or invasive coronar angiography * capability to give informed consent

Exclusion criteria

* general: non-compliance, \<18 years of age, pregnancy * contraindications for CMR (non-CMR compatible device, chronic kidney disease (eGFR \<30ml/min), allergies (medications)

Design outcomes

Primary

Measure	Time frame	Description
Quantitative Perfusion	assessment of CMR and invasive data within 24hours	Correlation of myocardial blood flow and perfusion reserve in CMR with invasively dervived fractional flow reserve (FFR), coronary flow reserve (CFR) and microcirculatory resistance (IMR)
Dual bolus vs dual sequence	assessment of CMR and invasive data within 24hours	Compare both CMR-derived quantitative perfusion for prediction of FFR/CFR/IMR

Secondary

Measure	Time frame	Description
Strain	baseline CMR data	Correlation of segmental perfusion and myocardial strain
Tissue characterisation	baseline CMR data	Correlation of segmental perfusion and T1/T2/ECV/LGE
Cardiovascular Hospitalisation (CVH)	12 months	CVH within 12 months

Countries

Germany

Contacts

Primary ContactSören Jan Backhaus, MD

s.backhaus@kerckhoff-klinik.de06032-996-2620

Backup ContactAndreas Rolf, MD

a.rolf@kerckhoff-klinik.de06032-996-2620

Outcome results