Skip to content

MRI Assessment of Knee Kinematics From Extension to Flexion - Exploratory Study

MRI Assessment of Knee Kinematics From Extension to Flexion - Exploratory Study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07016906
Acronym
FLEXIGEN
Enrollment
36
Registered
2025-06-12
Start date
2025-07-08
Completion date
2026-09-30
Last updated
2026-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteer

Brief summary

During flexion of the knee, internal rotation of the tibia associated with translation of the tibial plateaus in relation to the femoral condyles is automatically induced. This mechanism combines a sliding phenomenon and a rolling phenomenon of the condyles on the plate, the latter being known as 'roll-back'. In 2024, imaging analyses of the knee, and in particular MRI, are carried out with the leg in extension. MRI of the knee at different degrees of flexion would enable to assess the sliding and roll-back phenomena, in order to gain a better understanding of knee kinematics. However, MRI of the knee at different degrees of flexion is limited by the size of the MRI machines and especially by the knee antennae, which are narrow and do not allow flexion beyond 30°. In this context, the only solution for carrying out an MRI study on knees in flexion would be to carry out this examination with an antenna that allows the knee to be positioned at different angles of flexion. This particular type of antenna only exists in veterinary schools, where they are used in particular for horses. Consequently, this study is based on the assumption that the kinematics of the knee can be assessed using MRI with an antenna for veterinary use.

Interventions

OTHERMRI

Knee MRI at different degrees of flexion

Sponsors

GCS Ramsay Santé pour l'Enseignement et la Recherche
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy volunteers (no damage to either knee) * Male or female, aged between 18 and 40 * Healthy volunteer affiliated to or benefiting from a social security scheme * A healthy French-speaking volunteer who has signed an informed consent form.

Exclusion criteria

* Contraindication to MRI * Joint osteoarthritis * BMI \> 30 * Previous trauma or surgery to the knee * Recurrence of sprains * Knee trauma other than sprain * Protected person: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision. * Pregnant or breast-feeding woman

Design outcomes

Primary

MeasureTime frameDescription
femorotibial knee kinematicsDay 1The kinematics of the knee will be described on the basis the femorotibial contact surfaces at the level of the medial tibial plateau and the lateral tibial plateau at each degree of flexion, during an MRI acquisition. Contact surfaces will be measured in mm2.

Countries

France

Contacts

CONTACTBertrand SONNERY-COTTET, MD
sonnerycottet@aol.com+33437530022

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 21, 2026