Essential Tremor
Conditions
Keywords
Temporal Interference, Essential Tremor
Brief summary
This single-center prospective study aims to investigate the treatment efficacy of temporal interference (TI) in essential tremor patients aged 30-70.
Detailed description
Temporal Interference (TI) technology is a novel non-invasive method for deep brain stimulation (DBS). By generating an overlapping electric field from safe currents, TI creates focused stimulation in targeted deep brain areas. This approach allows for the exploration of deep brain nuclei functions and has the potential to serve as a non-invasive alternative to traditional invasive DBS for clinical treatments. This study aims to investigate the treatment efficacy of TI deep brain stimulation by including essential tremor patients aged 30-70. Before and after TI stimulation, clinical data will be recorded. Clinical and imaging data will be analyzed and processed to advance the treatment of essential tremor.
Interventions
Researchers apply temporal interference (TI) stimulation to the deep brain nuclei of essential tremor patients.
Sponsors
Liankun_Ren
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Aged 30-70 years old, regardless of gender. Action tremor and postural tremor in both upper limbs, or action tremor and postural tremor in one limb; * No history of mental diseases; * Informed consent signed.
Exclusion criteria
* Presence of other neurological diseases affecting the study (such as epilepsy); * Patients with moderate to severe cognitive impairment (Montreal Cognitive Assessment ≤ 18 points); * Orthopedic diseases that may affect motor symptoms; * Patients taking antipsychotic or antidepressant medications; * Presence of metal implants in the body (such as brain pacemakers or cardiac pacemakers); * History of electroconvulsive therapy; * Presence of cardiovascular risk factors, etc.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tremor Level Evaluation | Up to 3 months after TI stimulation | Percentage change in per month after stimulation from baseline in The Essential Tremor Rating Assessment Scale(TETRAS) score. The TETRAS score ranges from 0 to 112, including an activities of daily living (ADL) section(0-48 scores) and a performance section(0-64 scores), with higher scores representing more severe tremor and lower scores indicating lower tremor level |
Countries
China
Contacts
Primary ContactLiankun Ren, MD
Outcome results
None listed