Eating Disorders
Conditions
Brief summary
Anorexia nervosa (AN) and bulimia nervosa (BN) are serious eating disorders (EDs) with significant morbidity and mortality. Genetic studies have shown associations between EDs and metabolic traits, and longitudinal studies indicate distinct weight trajectories in children who later develop AN or BN, suggesting early involvement of metabolic factors. Biological studies also reveal differences in immune and neurotrophic markers in individuals with EDs compared to controls. Intriguingly, metabolites measured in neonatal blood could serve as very early markers of ED risk, unconfounded by state or scar factors related to prolonged starvation. Here the investigators propose to comprehensively analyze neonatal biomarkers (metabolic, immune, and neurotrophic), epidemiological factors, and genetics to understand ED risk and develop risk prediction models
Interventions
None listed
Sponsors
Karolinska Institutet
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
\- in PKU-register with or withou life-time diagnosis of anorexia or bulimi nervosa
Exclusion criteria
* not in PKU register
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metabolomic factors measured by mass-spectrometry | Sampled at birth (day 1) | Metabolomic factors such as amino acids, sugars, lipids, and organic acids extracted from dried blood spots sampled at birth are measured by mass spectrometry |
Countries
Sweden
Outcome results
None listed