Severity of Sarcopenia in Parkinson's Disease

Investigation of Sarcopenia Severity in Patients With Parkinson's Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07014514

Enrollment

Registered

2025-06-11

Start date

2025-06-20

Completion date

2025-10-25

Last updated

2026-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson Disease

Keywords

sarcopenia, ultrasonography

Brief summary

This study aimed to determine the prevalence of sarcopenia and dynapenia in Parkinson's disease patients, classified into early-stage (\<2.5) and moderate-stage (≥2.5) according to the Modified Hoehn and Yahr scale, and healthy controls using the ICF-based ISarcoPRM algorithm, and to examine the differences in regional muscle morphology, muscle strength, and physical performance between groups.This study was conducted as a cross-sectional research. The study included 43 Parkinson's disease patients aged 50-75 years, classified as stages 1-3 according to the Modified Hoehn-Yahr Scale, and 22 healthy individuals with similar demographic characteristics. Parkinson's disease patients were divided into two subgroups according to the Modified Hoehn-Yahr Scale: early stage (\<2.5) and intermediate stage (≥2.5). Demographic information of all participants was recorded, and clinical evaluations were performed. Parkinson's disease staging was assessed using the Modified Hoehn-Yahr Scale. Muscle mass was assessed using ultrasonography to measure anterior femoral muscle thickness. Muscle strength was measured by handgrip strength, and physical performance was assessed using a five-count sit-up test.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Score between 24 and 30 on the Mini Mental State Examination * Be diagnosed with Parkinson's Disease by a neurologist * Stage 1-3 on the Modified Hoehn and Yahr Scale

Exclusion criteria

* Inability to communicate verbally * Elderly people with severe visual impairment, neurological disorders in addition to Parkinson's and/or congestive heart failure * Older adults in whom exercise is not recommended

Design outcomes

Primary

Measure	Time frame	Description
Ultrasonographic Measurement	Baseline	For sarcopenia evaluation, anterior thigh muscle thickness will be measured by ultrasonography.
Five Times Sit to Stand Test	Baseline	This test measures the time it takes for an individual to stand up and sit down 5 times as quickly as possible, starting from a sitting position without using their arms.
Hand Grip Strength	Baseline	In this test, the individual will sit on a chair with their feet flat on the floor. The Jamar Hand Dynamometer will be used for measurement. They will be asked to squeeze the dynamometer firmly with their shoulders adducted and in neutral rotation, their elbows in 90-degree flexion, their forearms neutral and supported, and their wrists neutral. 3 repetitions will be done and the average will be taken.

Countries

Turkey (Türkiye)

Contacts

STUDY_CHAIRSüleyman Korkusuz, PhD

Atılım University

STUDY_CHAIRAyla Fil Balkan, Assoc Prof

Hacettepe University

STUDY_CHAIRGül Yalçın Çakmaklı, Assoc Prof