Tranexamic Acid to Reduce Blood Loss in Women Having Planned Cesarean Section

Role of Tranexamic Acid in Control of Intraoperative Blood Loss in Women Undergoing Elective Cesarean Section

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07013812

Enrollment

Registered

2025-06-10

Start date

2023-11-01

Completion date

2024-04-30

Last updated

2025-06-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Loss During Surgery, Cesarean Section

Keywords

Tranexamic acid, Elective Cesarean Section, Intraoperative blood loss

Brief summary

This clinical trial was done to find out if tranexamic acid (TXA) can safely reduce the amount of blood loss during cesarean (C-section) deliveries. Heavy bleeding is a major risk during childbirth, especially in C-sections, and can be life-threatening. The main question this study wanted to answer was: Does giving tranexamic acid before surgery reduce the amount of blood lost during a planned C-section? In this study, 68 women who were scheduled for elective (planned) C-section deliveries were randomly assigned to receive either tranexamic acid or a placebo (a look-alike substance with no medicine in it) before surgery. The medication was given by slow injection just 15 minutes before the operation. All surgeries followed the same procedure and were done by experienced obstetric surgeons. The amount of blood lost during surgery was carefully measured and compared between the two groups. The goal was to find a simple and safe way to lower the risk of blood loss and its complications during C-sections, improving outcomes for mothers.

Interventions

DRUGTranexamic Acid (IV)

One gram (10 ml) intravenous injection

DRUGDextrose 5% (D5W)

5% dextrose water intravenously

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Women age 20-45 years * at 37-40 weeks of gestation (on LMP) * Planned to undergo cesarean section under spinal anesthesia

Exclusion criteria

* Women with previous history of thromboembolic events * Allergy to tranexamic acid * Women with morbidly adherent placenta (on antenatal USG)

Design outcomes

Primary

Measure	Time frame	Description
Blood Loss	During the elective cesarean section procedure	Intraoperative blood loss (ml) was measured by taking weight difference of the dressings and towels before and after the operation plus blood added to the fluid volume inside the suction apparatus.

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026