Periodontal Disease
Conditions
Keywords
Periodontal disease, Diode laser, Non-surgical periodontal therapy, Gingival crevicular fluid, IL-1B, IL-6, IL-8, TNF, Laser dentistry, Periodontitis, Yemen
Brief summary
The aim of this study is to evaluate the efficacy of diode laser in addition to periodontal treatment in periodontitis patients and to investigate their effects on gingival crevicular fluid (GCF) cytokine levels before and after treatment, among some Yemeni individuals in Sana'a city.
Detailed description
This study aims to compare the clinical and immunological effects of traditional mechanical debridement alone versus combined treatment with diode laser (high and low power). The clinical parameters include Plaque Index (PI), Gingival Index (GI), Periodontal Pocket Depth (PPD), and Clinical Attachment Loss (CAL). Immunological parameters include IL-1β, IL-6, IL-8, and TNF-α levels in GCF. Participants will be selected from the Yemeni population residing in Sana'a City. The study will include a control group receiving conventional therapy and two test groups receiving diode laser therapy with high and low intensity settings, respectively. Measurements will be recorded at baseline (T0), one month after treatment (T1), and three months post-treatment (T2). The goal is to determine whether adjunctive diode laser therapy provides additional clinical and immunological benefits compared to conventional treatment alone.
Interventions
PROCEDUREHigh power diode laser + SRT
2W laser will be applied to periodontal pockets
PROCEDURELow diode diode laser + SRT
A 0.5W low laser is applicated to periodontal pockets after mechanical debridement
PROCEDURECurettage (SRT) only
Mechanical debridement for pocket
Sponsors
University of Science and Technology, Yemen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
This is a three-arm parallel assignment study comparing the effects of different periodontal treatments in patients with periodontitis. Participants were randomly assigned to one of the following groups: (1) scaling and root planing (SRP) alone, (2) SRP combined with high-power diode laser, or (3) SRP combined with low-power diode laser. The study aimed to evaluate changes in clinical periodontal parameters and inflammatory cytokine levels in gingival crevicular fluid at baseline, 1 month, and 3 months after treatment.
Eligibility
Sex/Gender
ALL
Age
25 Years to 58 Years
Healthy volunteers
Yes
Inclusion criteria
1. Patients diagnosed with generalized periodontitis (presence of bleeding on probing \[BOP\] and probing pocket depth \[PPD\] ≥ 4 mm) 2. Age between 25 and 58 years 3. Presence of at least 20 natural teeth present.
Exclusion criteria
1. Smokers or qat chewers 2. Pregnant or lactating women 3. Patients taking medications that may influence periodontal tissue status 4. Patients with systemic conditions affecting periodontal health 5. Patients who received periodontal therapy or antibiotic treatment within the last 3 months 6. Patients wearing intraoral appliances or having dental prostheses
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plaque Index (PI) | Baseline,1 month, 3months after treatment | Clinical evaluation of plaque index will be performed at three points before treatment (T0), 1 month (T1) anD 3 months (T2) after treatment to evaluate periodontal improvement |
| Gingival Index( GI) | Baseline,1 month, 3months after treatment | Clinical evaluation of gingival index will be performed at three points before treatment (T0), 1 month (T1) anD 3 months (T2) after treatment to evaluate periodontal improvement |
| Periodontal Pocket Depth (PPD) | Baseline,1 month, 3months after treatment | Clinical evaluation of periodontal pocket depth will be performed at three points before treatment (T0), 1 month (T1) anD 3 months (T2) after treatment to evaluate periodontal improvement |
| Clinical attachment level (CAL) | Baseline,1 month, 3months after treatment | Clinical evaluation of clinical attachment level will be performed at three points before treatment (T0), 1 month (T1) anD 3 months (T2) after treatment to evaluate periodontal improvement |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| interleukin-6 (IL-6) levels in GCF | Baseline,1 month, 3months after treatment | Levels of interleukin-6 (IL-6) in gingival crevicular fluid (GCF) will be measured at baseline, 1 month, and 3 months after treatment to assess immune response to o assess immune response to periodontal therapy. |
| interleukin-1B (IL-1B) levels in GCF | Baseline,1 month, 3months after treatment | Levels of interleukin-1 beta (IL-1β) in gingival crevicular fluid (GCF) will be measured at baseline, 1 month, and 3 months after treatment to assess immune response to periodontal therapy |
| interleukin-8 (IL-8) levels in GCF | Baseline,1 month, 3months after treatment | Levels of interleukin-8 (IL-8) in gingival crevicular fluid (GCF) will be measured at baseline, 1 month, and 3 months after treatment to assess immune response to o assess immune response to periodontal therapy. |
| tumor necrosis factor-alpha (TNF-α) levels in GCF | Baseline,1 month, 3months after treatment | Levels of tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF) will be measured at baseline, 1 month, and 3 months after treatment to assess immune response to o assess immune response to periodontal therapy. |
Countries
Yemen
Contacts
STUDY_CHAIRWaddah N Al-Hajj, Assoc prof
Faculty of dentistry -Thamar university
Outcome results
None listed