Symptomatic Uterine Fibroid
Conditions
Brief summary
39 women with symptomatic uterine fibroid with serum vitamin D deficiency will receive vitamin D3 supplementation for 6 month.then symptoms and size of fibroid will be re evaluated..
Detailed description
Effects of vitamin D supplimentation on symptomatic uterine fibroid will be checked
Interventions
DRUGColecalciferol (Vitamin D3) 50000 UI
Participants will received vit d upto 6 months
Sponsors
Nahida Akter
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
.Women aged between 18-50 not currently pregnant, lactating, or planning to conceive during the study period. * Women with a confirmed diagnosis of uterine fibroids (leiomyoma) through ultrasound. * Serum 25-hydroxyvitamin D \[25(OH)D\] levels below 20 ng/mL (indicating vitamin D deficiency). * Presence of symptoms associated with uterine fibroid, such as menorrhagia (heavy menstrual bleeding), or bulk-related symptoms (e.g., urinary frequency). * Participants should be generally healthy, with no history of other chronic illnesses that could affect the study's outcomes (e.g., autoimmune diseases, cancers, severe liver or kidney diseases). * Willingness to provide written informed consent for participation in the study. * No current use of hormonal therapy, other vitamin D supplements, or medications known to influence calcium metabolism or uterine fibroid growth (e.g., GnRH agonists, anti-estrogens). * Participants must be willing and able to adhere to the study protocol, including attending follow-up visits and completing any required assessments or tests.
Exclusion criteria
* Women younger than 18 or older than 50 years. * Serum 25-hydroxyvitamin D \[25(OH)D\] levels of 20 ng/mL or higher. * Women without a confirmed diagnosis of uterine fibroids (leiomyoma) through imaging. * Pregnant or breastfeeding women, or those planning to conceive during the study period. * Presence of chronic illnesses such as autoimmune diseases, cancers, or severe liver or kidney disease that could interfere with the study's outcomes. * Current or recent use of hormonal therapy, other vitamin D supplements, or medications that affect calcium metabolism or uterine fibroid growth (e.g., GnRH agonists, anti-estrogens). * Women who have undergone surgical interventions (e.g., myomectomy, hysterectomy) or other medical treatments specifically for uterine fibroid within the past 6 months. * Women with conditions like hyperparathyroidism or calcium disorders that might affect vitamin D metabolism or fibroid growth.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of Vitamin D3 supplementation on symptomatic uterine fibroid in women with Vitamin D deficiency. | 18 months | Fibroid size by cm |
Countries
Bangladesh
Contacts
Primary ContactNahida Akter, MBBS
Outcome results
None listed