Enhanced Recovery After Surgery Promotes the Rehabilitation of Patients With Acute Gastrointestinal Perforation in Perioperative Period

Enhanced Recovery After Surgery Promotes the Rehabilitation of Patients With Acute Gastrointestinal Perforation, a Randomized Controlled Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07008313

Enrollment

362

Registered

2025-06-06

Start date

2018-10-01

Completion date

2023-01-31

Last updated

2025-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Gastrointestinal Perforation, Enhanced Recovery After Surgery

Keywords

acute gastrointestinal perforation, enhanced recovery after surgery, perioperative period

Brief summary

The enhanced recovery after surgery(ERAS) has been gradually extended from its initial colorectal surgery to almost all surgical fields. However, there are few reports about the application value of ERAS in emergency surgery. The goal of this clinical trial is to evaluate the value of ERAS in the perioperative period of acute gastrointestinal perforation. All the patients will be treated by emergency operation. The changes of CRP, PA, PCT in Plasma 1 hour before operation and 1,3,7 days after operation, the operation time, the amount of bleeding during operation, the recovery time of intestinal function and the time of the first meal after operation,the incidence of postoperative complications, the degree of postoperative pain, the time of first out-of-bed activity, fatigue and mental status, quality of life, the length and the cost of hospital stay will be monitored and recorded.

Interventions

BEHAVIORALThe enhanced recovery after surgery

Enhanced recovery after surgery (ERAS) refers to a series of optimal management measures which are proved to be effective by evidence-based medical evidence in order to reduce patients' psychological and physiological traumatic stress reaction

BEHAVIORALTraditional treatment methods.

Traditional treatment methods.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

14 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Age≥14years old and ≤80 years old * The initial diagnosis is acute gastrointestinal perforation

Exclusion criteria

* Patients with unconsciousness,or patients with past psychiatric history * Patients with shock and/or severe organ failure * Patients who are pregnant * Patients with severe spinal deformity who are unable to receive epidural anesthesia

Design outcomes

Primary

Measure	Time frame
change of the c-reactive protein in plasma	1, 3, and 7 days after surgery
change of the prealbumin in plasma	1, 3, and 7 days after surgery
change of the procalcitonin in plasma	1, 3, and 7 days after surgery

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026