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Perinatal Thymic DYsregulation: Characterization of Perinatal Mood Episodes

Perinatal Thymic Dysregulation: Characterization of Perinatal Mood Episodes

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07008183
Acronym
DYP
Enrollment
200
Registered
2025-06-06
Start date
2025-10-13
Completion date
2026-12-31
Last updated
2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perinatal Mental Health

Keywords

perinatal mental health, perinatal depression, perinatal bipolar troubles

Brief summary

The perinatal period is recognized as a time of heightened psychological vulnerability. This research aims to improve the diagnosis and therapeutic management of mood episodes occurring during this time. It is integrated into routine clinical care and seeks to standardize the evaluation of criteria used to characterize mood episodes, while also exploring relevant contextual factors. Traditionally, clinical attention has focused on postnatal depression; however, increasing evidence highlights the presence of hypomanic symptoms-such as distractibility, reduced need for sleep, tachypsychia, and irritability-during the postpartum period. These symptoms may coexist with depressive features, resulting in complex clinical presentations that are often difficult to recognize and manage. Consequently, many cases go undiagnosed and untreated. Current research has largely concentrated on depressive episodes (perinatal depression), with less emphasis on manic, hypomanic, or mixed episodes indicative of bipolar disorder. A systematic evaluation of hypomanic symptoms occurring alongside depressive symptoms in the postpartum period could refine clinical diagnosis and support more targeted and effective therapeutic interventions.

Interventions

Patients who volunteer to take part in the research will complete self-questionnaires before their appointment with the psychiatrist.

Sponsors

Centre Hospitalier Charles Perrens, Bordeaux
Lead SponsorOTHER_GOV

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Intervention model description

Participants are assigned prospectively to complete self-questionnaires according to the protocol to characterize perinatal mood episodes.

Eligibility

Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Women over 18 years old * Pregnant or having given birth less than a year ago * First psychiatric consultation for the pregnancy concerned. * Good command of the French language. * Participant affiliated to the social security system * Participant who has given her consent to take part in the study.

Exclusion criteria

* Women who gave birth more than a year ago. * Participant under psychiatric care * Participant under court protection

Design outcomes

Primary

MeasureTime frameDescription
Detailed description of the Edinburg Postnatal (EPDS) scale1 dayA sensitivity analysis will be carried out on the group of patients with an EPDS score greater than 12, and a comparison between these patients and patients with an EPDS score equal to or less than 12 will also be carried out
Detailed description of Multidimensional Assessment of Thymic (MAThyS) scale1 day

Secondary

MeasureTime frameDescription
Association of the risk factors Perceived Stress Scale (PSS) will be assessed by self-report1 daythe level of perceived stress by self report score\>=14 characterize a high level of perceived stress
Association of the risk factors Medical Outcomes Study -Social Support Survey (MOS-SSS) will be assessed by self-report1the level of perceived social support by self-report scale scores can range from 19 to 95, with a median score of 57
Association of the risk factors Perceived Professional Social Support (QSSP-P) will be assessed by self-report1the level of perceived social support in the professional by self-report. scale scores pcan range from 12 to 120, with a median score of 66

Countries

France

Contacts

Primary ContactAnne-Laure SUTTER DALLAY, Prof, MD, PhD
alsutter@ch-perrens.fr+33 556561782
Backup ContactHelen SAVARIEAU
hsavarieau@ch-perrens.fr+33556563556

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026