Osteoarthritis
Conditions
Brief summary
The purpose of this study is to examine the natural history and risk factors of osteoarthritis (OA) and to explore the relationship between metabolic factors and OA progression.
Detailed description
1. To investigate the natural history of osteoarthritis (OA) in a large-sample cohort. 2. To identify OA phenotypes and their relationship with clinical symptoms and functional impairment. 3. To analyze metabolic factors (e.g., obesity, diabetes, and hypertension) as risk factors for OA onset and progression. 4. To evaluate the association between radiographic changes and OA symptoms. 5. To develop predictive models for OA progression and identify high-risk individuals for early intervention. Design: This is a prospective cohort study. Participants: The study will recruit approximately 4,000 individuals aged 50 years and above. Participants will undergo baseline assessments, including demographic data collection, medical history, dietary evaluation, physical examination, blood sample collection, and radiographic imaging. Annual follow-ups will be conducted over 10 years to monitor OA progression and related risk factors.
Interventions
None listed
Sponsors
Beijing Tsinghua Chang Gung Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Inclusion criteria
* Aged 50 years and above * Long-term resident of the study area * Willing to participate and provide informed consent
Exclusion criteria
* Hearing, speech, or mental impairments preventing effective communication * Unable to complete scheduled follow-up visits * Pregnant or planning pregnancy during the study period * Any other condition deemed unsuitable for participation by the researchers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Osteoarthritis | Annually for 10 years | The occurrence of clinically diagnosed osteoarthritis based on imaging and clinical symptoms during the follow-up period. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Physical Function (WOMAC Subscale) | Annually for 10 years | Assessed using the WOMAC physical function subscale (range: 0-68). Higher scores indicate worse physical function. |
| Change in Physical Function (SF-36 Physical Function Domain) | Annually for 10 years | Assessed using the SF-36 physical function domain (range: 0-100). Higher scores indicate better physical function. |
| Timed Up and Go Test (TUGT) | Annually for 10 years | Measured in seconds; a shorter time indicates better mobility. |
| Five Times Sit-to-Stand Test (5TSTS) | Annually for 10 years | Measured in seconds; a shorter time indicates better lower limb strength and function. |
| Radiographic Progression of Osteoarthritis | Annually for 10 years | Measured by changes in Kellgren-Lawrence (K-L) grade in bilateral knee X-rays over time. |
| Changes in Body Mass Index (BMI) | Annually for 10 years | Measured in kg/m². Analyzed for correlation with radiographic progression of osteoarthritis using the Kellgren-Lawrence grading system. |
| Change in Joint Pain Severity (WOMAC Pain Subscale) | Annually for 10 years | Evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale (range: 0-20). Higher scores indicate worse pain. |
| Changes in Fasting Glucose | Annually for 10 years | Measured in mg/dL using venous blood samples collected after an overnight fast. |
| Changes in Total Cholesterol (TC) | Annually for 10 years | Measured in mmol/L or mg/dL using fasting venous blood samples. |
| Changes in Low-Density Lipoprotein Cholesterol (LDL-C) | Annually for 10 years | Measured in mmol/L or mg/dL using fasting venous blood samples. |
| Changes in High-Density Lipoprotein Cholesterol (HDL-C) | Annually for 10 years | Measured in mmol/L or mg/dL using fasting venous blood samples. |
| Changes in Triglycerides (TG) | Annually for 10 years | Measured in mmol/L or mg/dL using fasting venous blood samples. |
| Changes in Blood Pressure | Annually for 10 years | Measured in mmHg using an automated sphygmomanometer to record systolic and diastolic blood pressure. |
Countries
China
Outcome results
None listed