Asthma, Occupational Asthma, Occupational Diseases
Conditions
Brief summary
Occupational exposure is known to cause 15% of asthma cases. The main treatment for occupational asthma is to stop exposure if possible. Although, remission of occupational asthma only occurs in only 30 % of patients after cessation of exposure. There is currently no way of predicting which patients will go into remission after cessation of exposure. In non-occupational asthma, the inflammatory biomarker T2 has allowed the entry into personalized medicine and can predict future exacerbations. The investigators hypothesize that T2 biomarkers could be predictive markers for remission in occupational asthma after exposure cessation. The investigators intend to carry out a follow-up study at the University Hospital of Strasbourg to perform the non-specific bronchial hyperresponsiveness test to assess remission in patients diagnosed with occupational asthma and to compare baseline T2 biomarkers in remission and non remission patients.
Interventions
OTHERMeasure of T2 biomarkers
T2 Biomarkers are estimated via induced sputum: Sputum is induced through increasing concentrations from 0.9 or 3% to 4% and 5% of hypertonic solution. Assessment of nonspecific bronchial hyperresponsiveness is realized by metacholine challenge
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age over 18 * Diagnosis of occupational asthma by specific inhalation challenge * Exposure to sensitizing agent avoided or reduced * Able to understand the aims and risks of the research and to give free and informed consent * For women of childbearing age: effective contraception in progress. * Benefiting from social security coverage
Exclusion criteria
* Impossibility of giving the subject informed information (subject in emergency situation, difficulties in understanding the subject) * Subject under court protection * Subject under guardianship or curatorship * Pregnant or breast-feeding patient
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Remission of occupational asthma | Day 1 | Remission of occupational asthma is defined by absence of nonspecific bronchial hyperresponsiveness. Assessment of nonspecific bronchial hyperresponsiveness is realized by metacholine challenge |
| Comparison of TH2-type inflammation levels | Day 1 | To compare the level of Th2-type inflammation in sputum from patients in remission versus patients with persistent asthma. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Remission of occupational rhinitis | Day 1 | Remission of occupational rhinitis is assessed by symptom score |
Countries
France
Outcome results
None listed