Fetal Growth Retardation, Fetal Neurodevelopmental Disorder
Conditions
Keywords
z-score, healthy reference range
Brief summary
This study aims to establish the z score reference ranges of fetal head circumference and other measurement of fetal measurements including biparietal diameter, fronto-occipital diameter, length of the corpus callosum, lateral ventricle, transverse cerebellar diameter, height of the vermis, anteroposterior diameter of the vermis，height and width of normal fetuses from 18 to 40 weeks' gestation. Method-A cohort-based study was conducted on low-risk singleton pregnancies with healthy fetuses. The measurement was performed using simple 2-dimensional MRI on the typical fetal standard view. The reference ranges were constructed according to gestational age (GA), biparietal diameter (BPD), as independent variables based on the best-fit models, both mean and standard deviation (SD).
Interventions
None listed
Sponsors
Guangzhou Women and Children's Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* The pregnant women in Born in Guangzhou Cohort Study
Exclusion criteria
* The fetuses with prenatal diagnosis of congenital heart disease or other congenital diseases. The fetuses who are high-risk neonates at the delivery.1) preterm infants; (2) infants with extremely low birth weight (ELBW) or who are small for gestational age (SGA);
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Birth | 20 weeks follow up | Healthy birth |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| low birth weight | 20 weeks follow up | Healthy birth |
Countries
China
Outcome results
None listed