Effect of Vegan Diet on Microbiome and Metabolism

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07003230

Enrollment

Registered

2025-06-04

Start date

2025-05-30

Completion date

2025-12-31

Last updated

2025-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vegan Diet

Brief summary

The goal of this interventional study is to investigate how vegan diet affects health in healthy volunteers, Men and women ages 20 - 30 years old. The main questions it aims to answer are: Change in Microbial community composition and metabolic alterations Changes in plasma metabolic profile. Researchers will compare changes in microbiota and plasma metabolites profile to see the influence of vegan diet in health. In the dietary trial, participants were first assigned to a 2-week omnivorous diet phase, then switched to a 2-week vegetarian diet phase

Interventions

DIETARY_SUPPLEMENTvegan and omnivorous diet

Participants underwent a 2-week omnivorous diet intervention, followed by a 2-week vegan diet intervention

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

healthe Participants, ages 20-30 years old

Exclusion criteria

1. Oral antibiotic use or acute/chronic inflammation within the past 3 months; 2. Hormone intake within the past 3 months; 3. Use of any known interfering medications (e.g., insulin, glibenclamide, indomethacin, phentolamine, furosemide, phenytoin sodium, cortisone, etc.) or probiotics within the past month that may affect glucose or lipid metabolism; 4. Smoking or alcohol consumption; 5. Uncontrolled mental disorders (including a history of psychiatric hospitalization); 6. Currently participating in a weight loss or weight management program; 7. Following a special or medically prescribed diet (e.g., for celiac disease); 8. Comorbid cardiac or renal insufficiency; 9. Chronic constipation; 10. Hypertension; 11. Diabetes mellitus.

Design outcomes

Primary

Measure	Time frame	Description
Gut microbiota composition in twenty participants	14days，28days	16S rDNA sequencing technology was used to identify the structural and functional changes of intestinal microbiota before and after vegan diet.

Secondary

Measure	Time frame	Description
Metabolomic profile of twenty participants in serum and feces	14days, 28days	To determine changes of the metabolomic profile in feces and serum after vegan diet

Countries

China

Contacts

Primary ContactZhanguo Liu

zhguoliu@163.com+86 13425766255

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026