Knee Osteoarthritis, Low Back Pain
Conditions
Keywords
ischemic preconditioning, restricted blood flow, knee pain, back pain
Brief summary
We are examining the use of restricted blood flow, through full occlusion, on a single thigh for 50 minutes (5 minutes on, 5 minutes off), completed every other day for 2 weeks to improve function in individuals with knee osteoarthritis and low back pain.
Interventions
DEVICEIschemic Preconditioning
The intervention arm will include full blood flow occlusion in one thigh for 5 minutes followed by 5 minutes of reperfusion for a cycle of 50 minutes.
DEVICESham Intervention
This intervention includes 25mmHg of pressure, which is not sufficient for blodo flow occlusion.
Sponsors
National Institute on Disability, Independent Living, and Rehabilitation Research
University of Illinois at Chicago
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Reported Knee Pain using ACR Criteria * Reported Back Pain using ODI Criteria \> 12 * Ability to walk for at least 3 minutes without the use of aids * Ability to provide written informed consent
Exclusion criteria
* Younger than 50 years old * History of Knee or Hip Replacements * History of steroid injection within the previous 6 months * Presence of neuromuscular joint condition that affects lower extremity function * History of blood clots in the leg or any condition in which compression of the thigh is contraindicated * History of heart failure or thrombosis * Allergic to ultrasound gel * History of spine surgery * Non-English speaker * Currently pregnant or intends to become pregnant during the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Preferred walking speed | At baseline (from enrollment) until end of intervention (3 weeks). | Changes in preferred walking speed (m/s) from intervention |
| Muscle strength | From baseline (enrollment) until end of intervention (3 weeks) | Change in quadriceps, hamstring, and hip strength |
| Patient Reported Outcomes | At baseline (enrollment) through the intervention (3 weeks) | Change in subjective function and reporting based on questionnaires |
| Gait Kinematics | At baseline (from enrollment) until end of intervention (3 weeks). | Changes in gait kinematics (in degrees) from intervention |
| Gait Kinetics/Moments | At baseline (from enrollment) until end of intervention (3 weeks). | Changes in gait kinetics (joint moments) (in N/m) from intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cartilage Health | From baseline (enrollment) until completion of intervention (3 weeks) | Change in knee cartilage thickness using ultrasound methods |
Countries
United States
Contacts
Primary ContactShraddha Sudhir
Outcome results
None listed