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Effectiveness Evaluation of the Mosquito-Free Campus Initiative on Dengue Fever Prevention and Control: A Cluster Randomized Controlled Trial

Effectiveness Evaluation of the Mosquito-Free Campus Initiative on Dengue Fever Prevention and Control: A Cluster Randomized Controlled Trial

Status
Not yet recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07002021
Enrollment
3940
Registered
2025-06-03
Start date
2025-06-15
Completion date
2026-06-01
Last updated
2025-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dengue, Infection Prevention

Keywords

health education, schools, China

Brief summary

The goal of this cluster randomized controlled trial is to evaluate the effect of health education interventions on the score of the knowledge, attitudes, and practices (KAP) of dengue in in primary and middle school students in the city of Guangzhou and Foshan in China. Individuals aged 6 to 15 years who are in grades 1-9 in primary schools in Guangzhou and Foshan will be enrolled. 20 primary schools will be randomly selected, with half designated as intervention group schools and the remaining half as control group schools. The intervention group will receive a health education intervention focused on dengue prevention every semester for 6 months, while the control group will continue with their routine school health education for 6 months. Researchers will compare the differences in the score of the KAP of dengue between the intervention and control groups after 6 months to see if health education can improve knowledge, attitudes and practices of dengue among primary and middle school students.

Detailed description

Introduction: Dengue is one of the fastest spreading mosquito-borne infectious diseases in the world. Guangdong, as the core epidemic area of dengue fever in China, has experienced many large outbreaks of dengue in history due to its warm and humid climate, dense urbanization, and frequent communication with Southeast Asia. However, prevention and control measures in schools remains suboptimal. This study aims to improve the knowledge, attitudes, and practices (KAP) of dengue prevention and control among students, and reduce the density of mosquito vectors and the risk of dengue transmission in primary and middle schools. Methods and analysis: This cluster randomized controlled trial will enroll 3940 students from 20 primary and middle schools in Guangzhou and Foshan City, China. Schools will be randomized to an intervention group receiving dengue health education and environmental governance or a control group receiving routine health education. The primary outcome is scores of KAP of students. Secondary outcomes include environmental mosquito vector index. Data will be collected through questionnaires, campus environment inspection, and self-reports at baseline and study conclusion. Ethics and dissemination: Ethical approval has been sought from the Ethics Committee of the School of Public Health, Sun Yat-sen University. Findings from the study will be made accessible to key stakeholders.

Interventions

COMBINATION_PRODUCTHealth education

The intervention group will receive a health education intervention focused on dengue prevention and campus environmental governance, while the control group will continue with their standard school health education without any additional intervention. An health education including the knowledge of dengue fever, harm of mosquitoes, and measures of mosquito control, will be developed and reviewed by an expert group. The campus environmental governance includes organizing campus environmental cleaning once a week, focusing on removing mosquito breeding places such as water containers.

Sponsors

Sun Yat-sen University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
6 Years to 15 Years
Healthy volunteers
Yes

Inclusion criteria

* Primary and middle school students within the age range of 6-15 years. * The primary and middle schools are located in Yuexiu District, Baiyun District of Guangzhou city or Nanhai District of Foshan City. * The schools have the necessary infrastructure, management level and resource allocation to participate in dengue fever prevention and control. * The schools agree to implement the intervention measures during the research period. * The schools are willing to provide baseline data and participate in subsequent assessments before the intervention is implemented.

Exclusion criteria

* Unwilling to participate in the project. * Participants (students or staff members) are unable to participate in the intervention or withdraw from the study due to personal reasons.

Design outcomes

Primary

MeasureTime frameDescription
scores of the knowledge, attitudes, and practices (KAP) of dengueFrom enrollment to the end of intervention in 6 monthsRegarding the knowledge, attitudes, and practices of dengue, each correct answer for the health literacy research questionnaire will be scored as one point, with incorrect answers receiving no points.

Secondary

MeasureTime frameDescription
mosquito vector indexFrom enrollment to the end of intervention in 6 monthsThe mosquito vector index will be calculated as the number of mosquitoes captured in a fixed area divided by the total area.

Contacts

Primary ContactLin Xu, PhD
xulin27@mail.sysu.edu.cn(86) 20-8733-5523
Backup ContactWeixiang Gao, Master
gaowx7@mail2.sysu.edu.cn(86) 17328625687

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026