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Lumbar Spinal Stenosis and Central Sensitization

The Relationship Central Sensitization, Pain and Depression Patients With Lumbar Spinal Stenosis

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07001982
Enrollment
81
Registered
2025-06-03
Start date
2025-06-17
Completion date
2025-10-15
Last updated
2026-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lumbar Spinal Stenosis

Brief summary

Lumbar spinal stenosis (LSS) functionally limits individuals by causing pain in both the waist and the legs during activity and walking. Pain is, therefore, an important problem for patients. Pain lasts for years in LSS and thus becomes chronically persistent. As a result, persistent pain can cause sensitization due to a decrease in the pain threshold. This condition affects patients not only biomedically but also biopsychosocially. For this reason, various sleep disorders and mood disorders can develop in patients. Therefore, this study aimed to examine the relationship between central sensitization and pain, disability, sleep and depression in patients with LSS.

Detailed description

Lumbar spinal stenosis (LSS) functionally limits individuals by causing pain in both the waist and the legs during activity and walking. In particular, the pain in LSS lasts for years and becomes chronic and can cause persistent and disturbing sensitization. This situation may be associated with decreased pain threshold and allodynia. Various studies show that sensitization can affect individuals biomedically and may lead to important health problems. Some of these are sleep and depression problems. Sleep and a healthy mentality are important for continuing daily activities and preserving quality of life. However, when the literature is examined, it is seen that central sensitization and the parameters that may be related to this have not been examined sufficiently. Therefore, the aim of this study is to examine the relationship between central sensitization and pain, disability, sleep and depression in patients with LSS.

Interventions

None listed

Sponsors

Karabuk University
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
45 Years to 80 Years

Inclusion criteria

* Diagnosed with lumbar spinal stenosis by MRI, * The ages of 45-80, * Low back and/or leg pain that has persisted for at least 3 months * Volunteer to participate in the study

Exclusion criteria

* Patients who did not agree to participate in the study, * Those with a history of serious neurological diseases such as Parkinson's, hemiplegia, multiple sclerosis, * Those who had undergone surgery in the lumbar region within the last year, * Those with advanced joint disease in the lower extremity, * Those with malignancy in the spine, * Those who had a previous operation for the lower extremity, * Those who had a pain or disability in other musculoskeletal joints, * Those who had a psychological disorder or peripheral vascular disease * Those who had any concurrent serious medical condition, including sepsis or cancer * Those who did not cooperate well were not included in the study.

Design outcomes

Primary

MeasureTime frameDescription
Central sensitizationBaselineCentral sensitization will be assessed with the "Central Sensitization Scale". The total score range is between 0-100 points. As the score increases, sensitization increases and 40 points and above are considered higher sensitization.
Pain severityBaselinePain intensity will be assessed with Numeric Rating Scale (NRS). NRS varies between 0-10 and the higher the score, the greater the pain.
Pain pressure thresholdBaselinePressure pain threshold will be measured with an algometer in kg. High values indicate a high pain threshold.
Disability levelsBaselineDisability will be measured by the Oswestry Disability Index. The total score ranges from 0-100 and the higher the score, the higher the level of disability.
Pain catastrophizingBaselineIt will be evaluated using the pain catastrophizing scale. The total score varies between 0-52. As the score increases, negative feelings and thoughts increase.
Sleep qualityBaselineSleep quality will be assessed with the Pittsburgh Sleep Quality Index. It is scored from 0 to 21, with higher scores indicating worse sleep quality.
DepressionBaselineThe Center for Epidemiological Studies Depression Scale (CES-D) will be used to assess depression.The total score is 0-60. As the score increases, depression increases.

Countries

Turkey (Türkiye)

Contacts

STUDY_DIRECTORMusa Güneş, PhD

Karabuk University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 23, 2026