Critical Illness, Enteral Nutrition Feeding, Hemodynamics, Intestinal Ischemia, Ultrasonography, Doppler
Conditions
Keywords
Enteral Nutrition, Critical Illness, Intestinal Ischemia, Hemodynamics
Brief summary
This study aims to address the challenges of enteral nutrition support in critically ill ICU patients with varying gastrointestinal function. We'll use bedside Doppler ultrasound to monitor superior mesenteric artery (SMA) blood flow changes post - feeding, exploring its correlation with Acute Gastrointestinal Injury (AGI) and other hemodynamic indicators. Our goals are to identify the patterns of SMA blood flow changes, establish a predictive model linking SMA blood flow reactivity to AGI risk, and propose individualized enteral nutrition strategies based on intestinal hemodynamics. Through this innovative approach, we hope to enhance the safety of enteral nutrition, reduce AGI incidence, and improve patient outcomes.
Interventions
OTHERenteral nutrition
We'll use an enteral nutrition intervention with intact protein formulations. Initiate nasogastric tube feeding at 20ml/h and continue for 24 hours. Adjust feeding strategies based on patients' SMA blood flow reactivity.
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Adults aged ≥18 years and ≤80 years. * Admitted to the study with a expected stay of more than 72 hours. * Require initiation of enteral nutrition support.
Exclusion criteria
* Pre-existing severe gastrointestinal diseases. * Patients with gastrointestinal bleeding. * Patients with bowel obstruction. * Pregnant or lactating women. * Patients with contraindications to bedside Doppler ultrasound.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| feeding intolerance | From enrollment to the end of treatment at 3 days | the incidence of feeding intolerance, defined as the frequency of feeding interruptions or reductions due to gastrointestinal complications like vomiting, gastric residuals, or abdominal distension during the study period. |
Countries
China
Outcome results
None listed