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Caffeine, Resistance Exercise and Muscle/Cerebral Oxygenation

Effect of Acute Caffeine Intake on Muscle and Cerebral Oxygenation During Muscular Strength, Power, and Endurance Performance

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07001176
Acronym
CAF+RE+Oxy
Enrollment
12
Registered
2025-06-03
Start date
2024-01-01
Completion date
2024-12-23
Last updated
2025-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caffeine and Resistance Exercise

Brief summary

Introduction: Several studies have evaluated and confirmed the ergogenic effects of acute caffeine intake on sports performance. However, the mechanism responsible for this ergogenic effect remains to be elucidated. Objectives: This study aims to evaluate the acute effects of caffeine intake on muscle and cerebral oxygen during muscular strength, power, muscle endurance performance. and muscle electrical activity in young adults.

Interventions

DIETARY_SUPPLEMENTCaffeine

Acute caffeine intake (3 mg/kg)

DIETARY_SUPPLEMENTPlacebo

Acute placebo intake (3 mg/kg)

Sponsors

University of Alcala
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)

Masking description

Statistician

Eligibility

Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* Age between 18 and 35 years. * Body Mass Index (BMI) < 25 kg/m². * Resistance-trained individuals (more than 2 years of structured training). * Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from exercising. * Participants must be able to perform the tests described in the following section.

Exclusion criteria

* History of neuromuscular diseases, heart disease, or conditions that may affect liver or muscle metabolism. * Use of drugs, stimulants, or sports supplements that could interfere with the dietary supplement used in the study. * Sedentary habits (less than 150 minutes/week of moderate exercise). * Having undergone prolonged periods of physical inactivity in the 6 months prior to the study. * Engaging in strenuous exercise within 48 hours prior to the tests. * Failure to replicate the same food intake on both experimental days. * Consumption of caffeine or any other stimulant after 6 pm on the day before the tests, to avoid headaches, discomfort, or lethargy in regular caffeine consumers.

Design outcomes

Primary

MeasureTime frameDescription
Muscle OxygenationThrough study completion, an average of 2 weeksMeasuring oxygen in the muscle before and after exercise.
Cerebral oxygenationThrough study completion, an average of 2 weeksMeasuring cerebral oxygenation before and after exercise.
Number of repetitions performed in 1 set at 65%1RM until task failureThrough study completion, an average of 2 weeks
Bar velocity deplacement performed in 1 set at 65%1RM until task failureThrough study completion, an average of 2 weeksIn bench press and back squat exercises
Power output generated in 1 set at 65%1RM until task failureThrough study completion, an average of 2 weeksIn bench press and back squat exercise

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026