Aphasia Following Cerebral Infarction, Hemiparesis After Stroke, Stroke
Conditions
Keywords
stroke, aphasia, hemiparesis, robotic
Brief summary
The goal of this clinical trial is to learn if a program that combines language and arm treatment can improve language and movement problems in people with chronic stroke. The mains questions it aims to answer are: * To determine the extent to which this combined treatment can improve language. * To determine the extent to which the combined treatment can improve arm movements. Researchers will compare the effects of this combined treatment with treatment that targets arm movements alone.
Interventions
BEHAVIORALCARAT: combined aphasia and robot-assisted arm therapy
Participants will receive 18 sessions of robot-assisted arm therapy combined with a standardized picture-word verification therapy task with the goal of improving language and arm movements.
BEHAVIORALRobot-assisted arm therapy
Participants will receive 18 sessions of robot-assisted arm therapy with the goal of improving arm movements.
Sponsors
National Institute on Deafness and Other Communication Disorders (NIDCD)
New York University
New York Medical College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1. Male or female patients between 18-90 years of age. 2. Right-handed prior to stroke 3. English-speaking (monolingual) 4. History of single left-hemisphere stroke at least 6 months prior to enrollment 5. Presence of aphasia and naming deficits on Western Aphasia Battery (WAB-R) 6. Comprehension score above 4 on WAB-R 7. Unilateral upper limb paresis (Fugl-Meyer Upper Extremity score \<56) 8. Documentation of signed Informed Consent by the study participant.
Exclusion criteria
1. Diagnosis or history of speech impairment prior to stroke 2. Severely limited speech output (score below 2 on spontaneous speech portion of WAB-R) 3. Inability to perform screening tasks due to severe language and/or cognitive impairment 4. Condition limiting passive movement in the range of motion required for robotic therapy (e.g. fixed contracture) 5. Any medical or psychiatric condition that may impact participation or compliance with study procedures or activities in the opinion of the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Philadelphia Naming Test | Baseline to 1 week post-treatment |
| Fugl-Meyer Upper Extremity Motor Assessment | Baseline to 1 week post-treatment |
Secondary
| Measure | Time frame |
|---|---|
| Apraxia Battery for Adults | Baseline to 1 and 4 weeks post-training |
| Stroke and Aphasia Quality of Life Scale-39 | Baseline to 1 and 4 weeks post-training |
| Apraxia of Speech Rating Scale | Baseline to 1 and 4 weeks post-training |
| Western Aphasia Battery-Revised Aphasia Quotient | Baseline to 4 weeks post-treatment |
| Box and Blocks Test | Baseline to 1 and 4 weeks post-training |
Other
| Measure | Time frame |
|---|---|
| Arm kinematics | Baseline to 1 and 4 weeks post-training |
| Arm vs. Non-Arm Naming | Baseline to 1 and 4 weeks post-training |
Countries
United States
Outcome results
None listed