Heat Acclimation and Thermotolerance, Hyperthermia
Conditions
Keywords
outdoor work, heat stress, kidney injury, cooling interventions
Brief summary
The investigators aim to test the effectiveness of two cooling interventions in reducing the core temperature of outdoor workers.
Detailed description
Workers in a variety of US industries-construction workers, welders, farmers, firefighters, and warehouse workers among them-are at risk for hyperthermia during work, yet very few interventions are being developed to mitigate heat related organ injury, particularly when workers do not have obvious symptoms of heat related illness. The investigators plan to test whether two active cooling technologies can help mitigate hyperthermia and risk for kidney injury. This work will enhance worker safety using evidence-based technology. To accomplish the aims of testing two active cooling interventions, the investigators plan to implement a case-cross over randomized control trial design at the work site conducted in partnership with an employer and with 30 workers at risk for hyperthermia. Over three sequential weeks, the investigators will measure rate of core temperature change (primary outcome). Secondary outcomes will include changes in kidney injury markers; changes in worker productivity; and worker acceptability of interventions.
Interventions
BEHAVIORALStandard Heat Illness Prevention Measures
Standard CAL-OSHA workplace heat illness prevention interventions, which require availability of cool, potable water; availability of shade when temperatures exceed 80F; and encouragement of rest for cool down breaks
OTHERCooling bandana
Cooling bandana embedded with a polymer to slow evaporation
OTHERCooling glove
Cooling glove with ability to circulate cool water interface with palmar skin
Sponsors
Stanford University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 18 2. Anticipated to be working in the same job category for the duration of the study 3. Able to communicate in English or Spanish
Exclusion criteria
1. Cannot provide informed consent 2. Weight less than 40 kg 3. Inability to swallow pills 4. Known history of having a pacemaker or ICD 5. Pregnancy as determined by self report and confirmed on Day 1 6. Gastrointestinal disorders (e.g., gastroparesis, prior surgery on GI tract with the exception of appendectomy or cholecystectomy, diverticulosis or inflammatory bowel disease) 7. Plan for an elective MRI in the 7 days post last planned pill ingestion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Core Temperature | up to 10 hours | Rate of core temperature change as measured by core temperature pill |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORShuchi Anand, MD
Stanford University
PRINCIPAL_INVESTIGATORJulie Parsonnet, MD
Stanford University
PRINCIPAL_INVESTIGATORMaria Montez Rath, mrath@stanford.edu
Stanford University
Outcome results
None listed