Postoperative Pain
Conditions
Keywords
transplantation, kidney, renal transplantation, Enhanced Postsurgical Recovery, Recovery, Enhanced Postsurgical, pain, postoperative, postsurgical pain
Brief summary
The goal of this interventional study is to learn if an Enhanced Recovery After Surgery (ERAS) protocol works to reduce the need for narcotic pain medications in live donor kidney transplant recipients. The main questions it aims to answer are: Does the ERAS protocol lower the amount of opioid narcotic medication needed to manage post-surgery pain? Does the ERAS protocol help lower pain scores after surgery? Researchers will compare the ERAS protocol to previous patients where the ERAS protocol was not used to see if the ERAS protocol works to reduce post-surgery pain. Participants will be asked to: * Drink a pre-surgery carbohydrate drink two hours before your surgery. * Take a pre-surgery dose of Tylenol by mouth. * Take a pre-surgery dose of Gabapentin by mouth. * The surgeon will administer a local numbing medication at the surgery site by injection during the surgery. * Begin walking with assistance about 12 hours after your surgery. * Allow the research staff to collect data about your kidney function. This data will be collected on your postoperative clinic visits, which generally occur about twice weekly for one month. This information will determine your kidney health, need for hospitalization, and side effects that may occur.
Interventions
DRUGAcetaminophen
650mg acetaminophen 30 minutes prior to surgery
DRUGGabapentin
300 mg gabapentin 30 minutes prior to surgery
DRUGBupivacaine
intraoperative local anesthetic
OTHERAmbulation
Assisted ambulation 12 hours after surgery
DIETARY_SUPPLEMENTpre-operative carbohydrate drink
50 g of carbohydrate drink 2 hours before surgery
Sponsors
Baylor Research Institute
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients * over 18 years of age * receiving a kidney transplant from a living donor.
Exclusion criteria
* delayed gastric emptying * severe type I diabetes * allergy to interventional medications * pregnancy (this is a normal exclusion for kidney recipients)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Numerical Rating Scale (NRS) (0-10) | From enrollment to the end of treatment at 30 days | Patient reported pain on a scale from 0 (no pain) to 10 (the worst possible pain) |
| Narcotic Use | From enrollment to the end of treatment at 30 days | milligram morphine equivalents (MME) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Adverse Events | From enrollment to the end of treatment at 30 days | unfavorable medical occurence |
| Hospital readmission | From enrollment to the end of treatment at 30 days | readmission to any hospital within 30 days |
| Length of Stay | From enrollment to the end of treatment at 30 days | total hospital length of stay |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORRichard Ruiz, MD
Baylor Scott & White All Saints Medical Center
Outcome results
None listed