Outcomes of PRF on Septoplasty in Patient With Nasal Septal Deviation

Effect of Platelet Rich Fibrin on Septoplasty :A Comparative Study

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06996106

Enrollment

100

Registered

2025-05-30

Start date

2025-06-30

Completion date

2026-02-01

Last updated

2025-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nasal Septal Srur, Nasal Septum; Deviation

Brief summary

The aim of this study is to assess the effectiveness of Platelet-Rich Fibrin (PRF) in improving postoperative healing, reducing complications, and enhancing functional outcomes in patients undergoing septoplasty

Detailed description

Septoplasty is a routine surgical intervention to correct nasal septal deviation, a major cause of nasal obstruction and chronic sinusitis. Despite advancements, postoperative complications-such as mucosal injury, synechiae, septal perforation, and hematoma-continue to impact outcomes and patient satisfaction. Platelet-rich fibrin (PRF), first described by Choukroun et al., represents an autologous biomaterial rich in growth factors like PDGF, TGF-β, VEGF, and IGF-1, known to accelerate wound healing and tissue regeneration. Unlike platelet-rich plasma (PRP), PRF is easier to prepare, does not require anticoagulants, and forms a fibrin matrix conducive to sustained release of cytokines. Several studies across disciplines-oral surgery, dermatology, orthopedics-support the regenerative potential of PRF. In nasal surgery, the delicate mucosal environment could benefit significantly from enhanced healing facilitated by PRF.

Interventions

OTHEREffect of Platelet Rich Fibrin on Septoplasty

it is a randomized trial of usage of platelet rich fibrin in septoplasty

Study design

Allocation

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

No minimum to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Adults aged 18-65 years undergoing septoplasty. Presence of cartilage deviated nasal septum requiring repair. No contraindications to PRF therapy.

Exclusion criteria

* History of coagulopathy or anticoagulant therapy. Active infection or systemic disease. Known hypersensitivity to PRF components. Previous nasal surgery Autoimmune or systemic inflammatory disease

Design outcomes

Primary

Measure	Time frame	Description
Effect of submucoperichondrial application of platelet rich fibrin on healing of nasal septum mucosa after septoplasty	postoperative at 1st week , 1st month , 3rd month	Mucosal Healing will be assessed by visual nasal endscope

Contacts

Primary Contact‪Ahmed ibrahim‬, M.B.B. Ch, Otorhinolary

ai731540@gmail.com0201014848903

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026