COPD, Quadriceps Muscle Atrophy
Conditions
Keywords
Clinimetric properties, Muscle mass, Muscle strength
Brief summary
A large amount of patients with COPD suffer from muscle dysfunction characterized by losses of muscle mass and strength. Studies have shown an association between a loss of quadriceps muscle mass and premature death. This study aims to investigate the clinimetric properties of a simple quadriceps perimetry and ShearWave elastography to improve the monitoring of skeletal muscle function in patients with COPD.
Detailed description
Muscle dysfunction in COPD is characterized by reduced skeletal muscle mass and strength, particularly in the lower limbs. These systemic consequences of COPD play a key role in the course of these patients, through their impact on functional status, quality of life and increased mortality. Early detection and monitoring of muscular status in these patients could help improve management and limit the consequences of the disease. Numerous studies show that variation in quadriceps mass has a significant relationship with premature mortality in this disease. The use of an indirect but simple and affordable measure: perimetric tape-measurement of thigh circumference, could help monitor quadriceps muscle mass in these patients on a regular and cost-effective basis. However, the clinimetric properties (validity, reliability, response to treatment) of this measurement need to be assessed to clarify its relevance. On the other hand, ShearWave ® elastography (SWE) is a new method of measuring quadriceps stiffness. This measurement could provide additional information on muscle quality compared with conventional measures of strength or muscle trophicity. The potential added value of SWE ® for COPD patients has not yet been investigated. This tool would provide more precise indications of the state of the quadriceps, with the aim of improving the management of this pathology.
Interventions
DIAGNOSTIC_TESTPerimetry and ShearWave measurement of the quadriceps muscle before and after a pulmonary rehabilitation (PR) programme
Patients will undergo a pulmonary rehabilitation (PR) programme. On day 1, perimetry and ShearWave measurements of the quadriceps muscle will be provided. Supplementary assessments of quadriceps thickness, quadriceps strength with a handheld dynamometry, lean body mass (bioelectrical impedance), constant work-rate endurance test and HAD questionnaire will also be provided on day 1. The same measurements and questionnaire will be provided on the last day of the patient in the PR programme.
Sponsors
Groupe Hospitalier du Havre
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* COPD patients * Adults (\>18 years old) * Patients starting a pulmonary rehabilitation (PR) programme
Exclusion criteria
* Patients included in other research protocol * Minors or under guardianship * Pregnancy * Patients with lower limb amputation or history of neuromuscular disease * Cardiovascular contradications for PR
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Perimetry of the quadriceps | At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program) | Thigh circumference measured by a tape |
| Quadriceps stiffness | At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program) | ShearWave elastography of the quadriceps muscle |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lean body mass | At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program) | measured by bioelectrical impedance |
| Functional exercise capacity | At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program) | measured as the endurance time during a constant load endurance test using a cycloergometer or a treadmill |
| Health-Related Quality of Life | At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program) | measured by quality of life questionnaire (hospital anxiety and depression scale (HAD)) |
| Quadriceps thickness | At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program) | measured by ultrasonography |
| Quadriceps strength | At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program) | measure of maximal voluntary contraction with handheld dynamometry |
Countries
France
Contacts
CONTACTClaire Dubois, PT
CONTACTYann Combret, PhD
Outcome results
None listed