Hyperdynamic, Intensive Care Unit, Left Ventricular Ejection Fraction, Mortality, Septic Shock
Conditions
Brief summary
The study aimed to evaluate the cause and prognosis of hyperdynamic left ventricular ejection fraction in critically ill patients with sepsis.
Detailed description
Cardiovascular dysfunction is increasingly being recognized as a significant complication in sepsis, affecting patient outcomes. Among the key parameters used to evaluate cardiac performance is the left ventricular ejection fraction (LVEF), typically assessed via transthoracic echocardiography (TTE). LVEF has been extensively studied; most investigations into preserved ejection fraction tend to group all values ≥50% together, thereby overlooking the potential clinical implications of LVEF ≥70%, often referred to as hyperdynamic LVEF (HDLVEF).
Interventions
DEVICETransthoracic echocardiography
Transthoracic echocardiography (TTE) was carried out. The assessment of left ventricular ejection fraction (LVEF) relied primarily on two-dimensional echocardiography using visual estimation.
Sponsors
Ain Shams University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age over 18 years. * Both sexes. * Patients who were diagnosed with septic shock.
Exclusion criteria
\- Patients with previously documented abnormal transthoracic echocardiography (TTE) findings, such as severe valvular disease, poor echocardiographic windows, patients admitted to cardiothoracic intensive care unit (ICU), and those not meeting sepsis criteria.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intensive care unit mortality | 28 days post-procedure | Such patients are admitted to the intensive care unit (ICU), where a definitive diagnosis of sepsis is established using the Sequential Organ Failure Assessment (SOFA) score. This validated scoring system is widely recognized for its ability to predict mortality by evaluating dysfunction across six critical organ systems: respiratory, cardiovascular, hepatic, coagulation, renal, and neurological. The SOFA score is initially calculated upon ICU admission and is subsequently updated every 24 hours, using the most abnormal clinical or laboratory values recorded during the preceding day. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Discharge against medical advice | 28 days post-procedure | Discharge against medical advice was recorded. |
| Incidence of patients who choose to leave the intensive care unit | 28 days post-procedure | Incidence of patients who choose to leave the intensive care unit against medical advice. |
Countries
Egypt
Outcome results
None listed