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Comparing Two Eccentric Protocols on Muscle Damage

A Novel Eccentric Resistance Training Strategy to Maximize Exercise Induced Muscle Damage in Young Adults

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06992271
Enrollment
16
Registered
2025-05-28
Start date
2023-03-08
Completion date
2025-06-01
Last updated
2025-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eccentric Hypertrophy, Muscle Damage

Brief summary

The purpose of this study will be to test whether a new way of weight training is more effective than typical weight training. The investigators expect that this new way will cause more exercise-induced muscle damage, which helps people build bigger muscles. Another purpose of this study will be to explore perceptions of how muscle soreness impacts participant activities of daily living.

Detailed description

Participants will come to the lab for 3 sessions, plus two email follow-up questionnaires. Session 1 (45 minutes) * Complete a demographic questionnaire * Self-assess muscle soreness * Walk on the treadmill to warm-up * Maximal voluntary contraction on the chest press * Two sets of eccentric (lowering) bench press at 75% of max Session 2 (45 minutes) * Walk on the treadmill to warm up * Maximal voluntary contraction on the chest press * Three sets of 10 eccentric contractions at 75% of max * Repeat the maximal voluntary contraction on the chest press Session 2 Follow-up Rate muscle soreness for each of the three days following Session 2 Answer open-ended questions about perceptions of the muscle soreness Session 3 (45 minutes) Walk on the treadmill to warm up Maximal voluntary contraction on the chest press Three sets of 10 eccentric contractions at 75% of max Repeat the maximal voluntary contraction on the chest press Session 3 Follow-up Rate muscle soreness for each of the three days following Session 2 Answer open-ended questions about perceptions of the muscle soreness

Interventions

BEHAVIORALFast Eccentric

Resistance training done quickly

BEHAVIORALSlow Eccentric

Resistance training done slowly

Sponsors

New York Institute of Technology
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE

Intervention model description

Crossover design with two groups

Eligibility

Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* Sixteen young adults (ages 18-35) will be enrolled in this study. * In order to be enrolled, they must have completed at least three months of resistance training in the past five years in order to minimize the learning effect and chance of injury.

Exclusion criteria

* Since regular resistance training reduces the primary outcomes, muscle damage and soreness, individuals who currently participate in chest press resistance training at least once per week will be excluded. * Individuals who have musculoskeletal injuries in the shoulder, elbow or wrist that preclude pain-free resistance training, or who have underlying uncontrolled cardiovascular complications will also be excluded. * Women who are pregnant, or may consider becoming pregnant over the subsequent 2 months, will be excluded

Design outcomes

Primary

MeasureTime frameDescription
Muscle soreness 11 dayVisual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness
Muscle soreness 22 daysVisual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness
Muscle soreness 33 daysVisual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness
Maximal Voluntary Isometric Contraction Changepre-intervention, immediately after the interventionChange in MVIC will be used to indicated muscle damage.

Countries

United States

Contacts

Primary ContactAmerigo Rossi, Ed.D
arossi01@nyit.edu516 686-3884

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026