Pregnancy in Diabetic, Placenta Diseases
Conditions
Brief summary
DW-MRI Allows a quantitative comparison of diffusion as an expression of tissue hypoxia. The investigators aim is to compare changes in placental diffusion in pregnant women with uncontrolled diabetes compared to healthy pregnant women using DW-MRI. The investigators hypothesize that placentas of diabetic mothers will show lower diffusion / perfusion compared to placentas of healthy women.
Detailed description
In highly uncontrolled diabetes there is an increased risk of intrauterine fetal death. The mechanism of fetal death is unknown and unpredictable. One of the theories points to hypoxia as a precursor to the death of the fetus in the womb. If the researchers succeed in predicting changes in the placenta with the help of MRI, it may be possible to understand the mechanism of fetal damage as well as in the future to develop a protocol for predicting pregnancies prone to fetal death in the womb.
Interventions
DIAGNOSTIC_TESTDW-MRI
Predict changes in ovarian diffusion using DW-MRI scan
Sponsors
Hillel Yaffe Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
The 2 arms will include 3th trimester pregnant women. Group 1- diabetic pregnant women Group 2- low risk pregnant women
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Women with PGAM (Pre-gestational diabetes) diagnosed before 20 weeks of pregnancy * Women with GDMA (Gestational diabetes) diagnosed by OGTT after 20 weeks of pregnancy
Exclusion criteria
* pregnant women with placental hypoxia disease related in the past * pregnant women with placental hypoxia disease related in the present * non-singleton pregnancy * women in active labor or rupture of membrane * smoking women * suspicion of placenta accreta
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Placental diffusion coefficient (D) measured by IVIM-DWI | Two years | Placental diffusion coefficient (D, mm²/s) derived from intravoxel incoherent motion diffusion-weighted MRI (IVIM-DWI). Mean D values will be extracted from whole-placenta regions of interest and compared between parturients with poorly controlled diabetes and excessive fetal growth and low-risk parturients with appropriately grown fetuses. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Placental perfusion fraction (f) measured by IVIM-DWI | Two years | Placental perfusion fraction (f, unitless) derived from intravoxel incoherent motion diffusion-weighted MRI (IVIM-DWI). Mean f values will be extracted from whole-placenta regions of interest and compared between parturients with poorly controlled diabetes and excessive fetal growth and low-risk parturients with appropriately grown fetuses |
Countries
Israel
Contacts
Primary ContactRinat Gabbay-Benziv, Prof
Backup ContactMoran Rotman, MD
Outcome results
None listed