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Impact of Minimally Invasive Non-surgical Periodontal Treatment on Infrabony Defects

Effects of Minimally Non-surgical Periodontal Treatment Versus Quadrantwise Subgingival Instrumentations on Infrabony Defects and Analysis of Defect Morphology on the Effectiveness of Treatment

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06992219
Acronym
Infra-MINST
Enrollment
52
Registered
2025-05-28
Start date
2022-10-01
Completion date
2024-11-30
Last updated
2025-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Intrabony Defect

Keywords

periodontitis

Brief summary

Fifty-two periodontitis patients (26 per group) were randomly assigned to the test (Minimally invasive non-surgical therapy - MINST) or the control group (Quadrantwise Subgingival Instrumentation - Q-SI) NPT protocols.

Detailed description

Clinical periodontal parameters, the number of pocket sites, x-ray of the infrabony defects characteristics and a composite outcome measure (COM) on the combined assessment of intrabony defect were recorded at baseline, and -3, 6- and at 12-months after treatment

Interventions

OTHERNon surgical periodontal treatment evaluated through probing pocket depth reduction

Patients were treated with Minimally invasive non surgical treatment (MINST) or quadrant-subgingival instrumentation (Q-SI). The efficacy of treatment in both groups was evaluated through Probin Pocket Depth reduction in millimetres measurement before and after treatment.

Sponsors

University of Catania
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Masking description

Sealed envelopes

Intervention model description

Non-surgical periodontal treatment Subgingival biofilm ultrasonic debridement with MINST or Q-SI for infrabony defects

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

* Diagnosis of Periodontitis

Exclusion criteria

* Periodontal treatment * Use of antibiotics, NSAIDs, and immunosuppressants during the last 6 months * Pregnancy

Design outcomes

Primary

MeasureTime frameDescription
Probing Pocket Depth Reduction1-yearProbing Pocket Depth Reduction in Probing Pocket Depth after treatment

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026