Sarcopenia, Sarcopenia in Elderly
Conditions
Brief summary
Population aging has become a significant global concern, and Taiwan is set to officially enter the super-aged society in 2025. As individuals age, various physiological functions gradually decline, including a reduction in muscle mass, which is a key aspect of the aging process. This interventional study aims to investigate the effects of leucine-rich protein combined with polyunsaturated fatty acid supplementation on middle-aged and elderly individuals (aged 50 and above) who are at high risk for sarcopenia.
Interventions
DIETARY_SUPPLEMENTAnimal-Based Oil Group
Participants in animal-based oil group will follow a diet in which the primary fat source is animal-based oil. The diet will supplement for 12 weeks.
DIETARY_SUPPLEMENTPlant-Based Oil Group
Participants in plant-based oil group will follow a diet in which the primary fat source is plant-based oil. The diet will supplement for 12 weeks.
Sponsors
Chang Gung University
Chang Gung Memorial Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
50 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Age ≥ 50 years * ASMI \< 7 kg/m2 in men * ASMI \< 5.7 kg/m2 in women * Grip strength \< 28 kg in men * Grip strength \< 18 kg in women * Walk speed \< 1 m/s
Exclusion criteria
* People who are allergic to supplements * cancer * heart failure * kidney disease * autoimmune disease * neurodegenerative disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| muscle mass | baseline, 12 weeks | Utilize Bioelectrical Impedance Analysis (BIA) to measure the Appendicular Skeletal Muscle Mass Index Level (ASMI) (kg/m\^2) |
| muscle function | baseline, 12 weeks | utilize handgrip dynamometer to measure the hand grip strength (kg). |
| physical function | baseline, 12 weeks | To assess the participant's walking speed over a 4-meter distance. |
Countries
Taiwan
Contacts
Primary ContactHsiang-Yu Tang, Ph.D.
Backup ContactYi Tsang Chen, Master of Science
Outcome results
None listed