FET, IVF, Low Molecular Weight Heparin, Recurrent Implantation Failure
Conditions
Brief summary
Recurrent implantation failure (RIF) is considered a tough problem in assisted reproductive technology (ART) without effective treatments. The effect of low molecular weight heparin (LMWH) in pregnancy outcomes is controversial. In addition, there are few reports on the role of LMWH in population with RIF performing freeze-thaw embryo transfer (FET) cycles. The purpose of this study is to evaluate the effect of LMWH on pregnancy outcomes in women with FET cycles.
Interventions
the LMWH group received injections of 4100 IU/d LMWH from the day of transplant
Sponsors
The Second Hospital of Shandong University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Women under or equal to the age of 40 when oocytes were retrieved; * The history of at least 2 failed fresh embryo transfer/FET cycles and cumulative transfer of ≥ 3 high-quality embryos or cumulative transfer of ≥ 2 blastocysts; * Planning to FET after IVF or ICSI cycles
Exclusion criteria
* Women with untreated hydrosalpinx, uterine cavity occupying lesions (uterine adhesions, submucous fibroids, endometrial polyps, et al.); * Women with abnormal anatomical structure of uterus (unicornuate uterus, bipedal uterus, et al.); * Women with endometrial thickness (EMT) \< 6mm on the day of transplantation; * Women or their partner with abnormal chromosome karyotype (not including chromosome polymorphisms); * Women with the history of recurrent spontaneous abortion (RSA); * Women with a history of autoimmune or coagulation disorders; * Women with contraindications to LMWH
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ongoing pregnancy rate | from transplantation to delivery (assessed up to 40 weeks of gestation) | The number of ongoing pregnancies divided by the number of women who received a transfer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| biochemical pregnancy rate | from transplantation to delivery (assessed up to 40 weeks of gestation) | The number of biochemical pregnancy cycles divided by the number of transplantation cycles |
| clinical pregnancy rate | from transplantation to delivery (assessed up to 40 weeks of gestation) | The number of clinical pregnancies divided by the number of women who received a transfer |
| ectopic pregnancy rate | from transplantation to delivery (assessed up to 40 weeks of gestation) | The number of ectopic pregnancies divided by the number of women who received a transfer |
| Miscarriage rate | from transplantation to delivery (assessed up to 40 weeks of gestation) | The number of miscarriages divided by the number of clinical pregnancies |
Countries
China
Outcome results
None listed