Antibiotic Therapy, Febrile Neutropenia, Febrile Neutropenia, Drug-Induced, Febrile Neutropenia, Rule of Clinical Decision, Chemotherapy, G-CSF
Conditions
Keywords
febrile neutropenia, chemotherapy-induced febrile neutropenia, Antibiotics, G-CSF
Brief summary
This study aim to find the best option for children having cancer who develop low immunity state due to chemotherapy
Detailed description
Children having a cancer diagnosis and treated with chemotherapy often develop neutropenia. This creates an immunocompromised state which can result in infections manifested by fever. This study compares two treatment options to find out the best treatment for these patients.
Interventions
DRUGAntibiotics only
Antibiotics alone
DRUGG-CSF
G-CSF & Antibiotic therapy in combination
Sponsors
University of Child Health Sciences and Children's Hospital, Lahore
King Edward Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* Age 1-16 years * any Gender * Febrile neutropenia * diagnosed case of solid or hematological malignancy * taking chemotherapy
Exclusion criteria
* Non-neutropenic fever * already received G-CSF or antibiotics before presenting to hospital * any other cause of neutropenia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Resolution of FN | 2 weeks | Duration of resolution of febrile neutropenia (in days) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Afebrile | 2 weeks | Duration of resolution of fever (in days) |
| Length of hospital stay | 2 weeks | Length of hospital stay (in days) |
Outcome results
None listed