Sarcoma
Conditions
Keywords
Imaging, sarcoma, cutting guide, MRI
Brief summary
The goal of this exploratory interventional study aims to evaluate the performance of pseudo-scanner MRI sequences in delineating the tumor extent within bone sarcomas and its ability to serve as a reference for designing cutting guides and enabling navigation during the surgical procedure, thus exploring the possibility of replacing the scanner to minimize exposure to ionizing radiation in patients with sarcoma.
Detailed description
The management of bone sarcomas is complex, and imaging plays an important role in both diagnosis and treatment monitoring. MRI is the method of choice to provide accurate information on the extent of the bone tumor and its relationship to adjacent soft tissues. However, an additional CT scan is routinely performed and combined with MRI images (spatial realignment) using software and relying on manual control and/or correction. This is essential during surgical planning to i) ensure resection with properly defined safety margins and ii) allow for accurate bone reconstruction.ing. This exploratory interventional study aims to evaluate the performance of pseudo-scanner MRI sequences in delineating the tumor extent within bone sarcomas and its ability to serve as a reference for designing cutting guides and enabling navigation during the surgical procedure, thus exploring the possibility of replacing the scanner to minimize exposure to ionizing radiation in patients with sarcoma.
Interventions
DEVICEWhole body MRI
Whole body MRI (ZTE sequence)
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
Whole body MRI in addition to the classic CT assessment for all participant.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosis of bone sarcoma with surgical indication
Exclusion criteria
* Implanted material incompatible with MRI. * Severe claustrophobia. * Pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of the absolute error of surgical margins | through study completion, an average of year | The error values observed in the study by Cartiaux et al. to assess the reduction in absolute error of surgical margins obtained when using a computer-assisted cutting procedure (using 3DSide software installed on a laptop belonging to 3Dside, made available to the doctoral student) compared to freehand cutting are used to size the present study. The objective is to compare the absolute error resulting from a cutting procedure assisted by this 3DSide software based on pseudo-scanner imaging with that resulting from the same procedure based on standard scanner imaging. |
Countries
Belgium
Contacts
Primary ContactFrédéric Lecouvet
Backup ContactPerrine Triqueneaux
Outcome results
None listed