Chronic Kidney Failure
Conditions
Brief summary
The goal of this observational study is to learn about the role of thoracic and whole body bioimpedance in the hemodynamic profile of patients with chronic kidney disease. The main question it aims to answer is: \- Is bioimpedance-determined fluid status associated with kidney function decline in patients with chronic kidney disease stage 3 - 5 (non dialysis).
Detailed description
Participants will be measured during their regular visit to their treating nephrologist. During a follow up of one year, 3 or 4 visits will be scheduled. * Bioimpedance and blood pressure measurements will be achieved by non-invasive techniques. * Blood sampling will as much as possible coincide with regular blood samplings for clinical purposes. * All subjects will undergo echocardiography at baseline and after one year follow up.
Interventions
None listed
Sponsors
Ziekenhuis Oost-Limburg
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Prevalent non-dialysis patients with estimated glomerular filtration rate \< 60 ml/min (for chronic kidney disease subjects) * Age \> 18 years * Signed informed consent
Exclusion criteria
* Acute kidney injury * estimated glomerular filtration rate \< 20ml/min directly post-nephrectomy * Clinical conditions affecting bioimpedance measurements: limb amputation, impaired skin integrity, brain stimulator, pacemaker with low threshold or unipolar pacemaker. * Clinical conditions affecting body composition: liver cirrhosis, active infectious disease or any acute cardiovascular event (defined as cerebrovascular event, myocard infarction, heart failure) during the 3 months before screening for inclusion * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| whole body fluid status | Baseline, every 3 months during 1 year | The primary objective is to associate the bioimpedance-determined fluid status \[fluid overload versus non-fluid overload\] with kidney function decline in patients with chronic kidney disease stage 3 (59-30ml/min), 4 (29-15ml/min) and 5 (\< 15 ml/min). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| identify the clinical factors associated with fluid overload during a longitudinal follow up | Baseline, every 3 months during 1 year | Secondary outcomes of interest are the central volume status (measured as ejection fraction in % by echocardiography and thoracic bioimpedance in Ohms in combination with photoplethysmography), the cardiac systolic and diastolic function (measured by echocardiography), cardiovascular events, hospitalizations, inflammatory- and nutrition status (by whole body bioimpedance measurements), and quality of life (by Short Form 36 questionnaire). |
Countries
Belgium
Outcome results
None listed