Heart Transplant Infection, Microsporidiosis Intestinal
Conditions
Keywords
microsporidiosis, Enterocytozoon bieneusi, Encephalitozoon intestinalis, Encephalitozoon hellem, solid organ transplant, heart transplant
Brief summary
The investigators propose to carry out a national retrospective study to collect epidemiological, biological, clinical and therapeutic data on microsporidiosis among heart transplant patients.
Detailed description
Microsporidia constitute a large family of intracellular eukaryotes infecting a wide range of hosts, ranging from insects to mammals and birds. Within this group, some species are responsible for intestinal syndromes manifested by abundant watery diarrhea, which can be particularly severe in immunocompromised individuals. In the 1980s, HIV-positive patients at the AIDS stage represented the primary population at risk. Nowadays, the most frequently affected patients among immunocompromised individuals are solid organ transplant recipients, for whom the management of this infection can be challenging. A neglected pathology until a few years ago, epidemiological data describing intestinal microsporidiosis in solid organ transplant recipients are scarce. The invesigators previously published the first data in kidney and liver transplant recipients. Here the investigators propose to carry out a national retrospective study to collect epidemiological, biological, clinical and therapeutic data on heart transplant patients.
Interventions
None listed
Sponsors
University Hospital, Clermont-Ferrand
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* heart transplant patients diagnosed with intestinal microsporidiosis * diagnosis made before December 31, 2024 in France (metropolitan France and overseas territories)
Exclusion criteria
-patient opposition
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Demographic data: age | 1 year | expressed in years old |
| Demographic data: sex | 1 year | choice between: male/female |
| Time between transplant and microsporidiosis | 1 year | expressed in days, or years if \>365 days |
| At diagnosis: number of days since the onset of symptoms | 1 year | expressed in number of days |
| Weight loss at diagnosis | 1 year | expressed in kilogram or in percent (compared to usual weight of the patient) |
| Dosage of immunosuppressants at diagnosis | 1 year | — |
| Time to stool negativation | 1 year | expressed in number of days between onset of treatment and first negative PCR during follow-up |
| Creatinine level in blood at Day 0 (diagnosis) and Month 3 | 3 months | expressed in µM |
| Numeration of cells in blood: platelets, lymphocytes, neutrophils at Day 0 (diagnosis) and Month 3 | 3 months | expressed in Giga per litre |
| Gammaglobulins in blood at diagnosis | 1 year | expressed in gram per litre |
Countries
France
Contacts
Primary ContactLise Laclautre
Outcome results
None listed