Advanced Right-sided Colon Cancer, the Extent of Lymph Node Dissection
Conditions
Brief summary
This is a prospective multicenter randomized controlled clinical study to explore the extent of lymph node dissection in progressive right hemicolon cancer and to elucidate the pattern of lymphatic drainage in the right hemicolon.
Interventions
PROCEDUREClearance with the left side of the SMV as the medial boundary
Undergo radical resection for right colon cancer with the left side of the SMV as the medial boundary
PROCEDUREClearance with the left side of the SMA as the medial boundary
Undergo radical resection for right colon cancer with the left side of the SMA as the medial boundary
Sponsors
Sixth Affiliated Hospital, Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Age: 18-75 years 2. Preoperative pathologic confirmation of adenocarcinoma 3. Tumor located in the region from the ileocecal valve to the right one-third of the transverse colon 4. American Society of Anesthesiologists (ASA) physical status classification I to III 5. Patients who have not received preoperative radiotherapy, chemotherapy, or immunotherapy 6. Preoperative imaging staging cT4N0M0 or cT3-4N+M0 7. Willing to participate in the study and sign the informed consent form
Exclusion criteria
1. Past medical history of malignant tumor 2. Patients with multiple primary tumors 3. Patients with a history of inflammatory bowel disease or familial adenomatous polyposis 4. Patients with distant metastasis 5. Pregnant or breastfeeding women 6. History of other previous major abdominal surgery 7. Patients requiring emergency surgery (including tumor perforation, obstruction, hemorrhage, etc.) 8. Those with other clinical and laboratory conditions deemed by the investigator to be inappropriate for participation in the trial
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Disease-Free Survival | The third postoperative year | It is defined as the proportion of patients from the start of randomization to the end of the third year without any of the following events: disease progression, local recurrence, distant metastasis, second primary colorectal cancer, or death from any cause. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| overall survival | The third postoperative year | The time from randomization to death from any cause. |
Countries
China
Contacts
Primary ContactJiaqi Ren
Backup ContactDechang Diao
Outcome results
None listed