Hyperuricemia
Conditions
Brief summary
To clarify the mechanism of stress on the incidence of hyperuricemia
Detailed description
To clarify the differences in intestinal microorganisms and metabolism between healthy people and hyperuricemia patients and across different level of stress
Interventions
OTHERNo interventions
No interventions
Sponsors
Shanghai 10th People's Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 69 Years
Healthy volunteers
Yes
Inclusion criteria
1. Obtain the informed consent of the subjects before conducting any trial-related activities; 2. Males aged 18-69; 3. The hyperurcemia group must meet the diagnostic criteria of having blood uric acid \>420umol/L measured twice on an empty stomach on different days under a normal purine diet;
Exclusion criteria
\- 1)Use of any uric acid-lowering drugs, anti-gout drugs, steroids, proton pump inhibitors, or non-steroidal anti-inflammatory drugs within one month before enrollment; 2)Use of any antibiotics, probiotics, or other drugs including traditional Chinese medicine within one month before enrollment; 3)Abnormal liver function, ALT and AST are more than 2.5 times the upper limit of normal; 4)Other diseases that affect glucose and lipid metabolism: hyperthyroidism, hypothyroidism, hypercortisolism, etc. 5)Chronic kidney disease or severe renal impairment, according to eGFR grading \<45mL/min/1.73m2; 6)Secondary hyperuricemia 7)Any gastrointestinal diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Phenotype differences in the gut microbiome by metagenomic sequencing. | Samples to be collected once per participant within 7 days of enrollment | including microbial composition analysis(Taxonomic Annotation Tools: MetaPhlAn4; Functional Gene Analysis Tools:eggNOG-mapper (functional classification) and diversity metrics(α-diversity (Shannon index) and β-diversity (Bray-Curtis distance, UniFrac distance) |
| sequencing results of the fecal metabolome in the population | Samples to be collected once per participant within 7 days of enrollment | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum uric acid | Samples to be collected once per participant within 7 days of enrollment | Uric acid in umol/L. |
Countries
China
Outcome results
None listed