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Oxidative Stress and Vitamin D Levels in Autism Spectrum Disorders

Oxidative Stress and Vitamin D Levels in Autism Spectrum Disorders: An Original Clinical Investigation

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06983379
Enrollment
68
Registered
2025-05-21
Start date
2020-01-03
Completion date
2023-01-30
Last updated
2025-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism Spectrum Disorders

Keywords

oxidative stress, Vitamin D, Autism Spectrum Disorders

Brief summary

Oxidative Stress and Vitamin D Levels in Autism Spectrum Disorders

Detailed description

Introduction: The etiology of Autism Spectrum Disorder (ASD) is thought to be complex. Increasing evidence in the literature shows that oxidative stress plays a role in the development and prognosis of autism. In our study, investigators aimed to investigate whether thiol disulfide balance, which is a new marker of oxidative stress, is different from that in normal children with autism spectrum disorder. Methods A total of 68 children, 38 with autism spectrum disorder and 30 healthy controls, were included in the study. Dynamic thiol balance, total oxidant status, total antioxidant status, ischemia-modified albumin, paraoxonase 1, and arylesterase activities were measured using colorimetric methods. Routine biochemical parameters were obtained from their files and evaluated.

Interventions

None listed

Sponsors

Alanya Alaaddin Keykubat University
CollaboratorOTHER
Mardin Artuklu University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
0 Years to 18 Years
Healthy volunteers
Yes

Inclusion criteria

Control group inclusion criteria: * Healthy children who applied to the pediatric clinic for routine examination Control group

Exclusion criteria

* Children who have any chronic medical diseases or psychiatric disorders * Children who have a family history of chronic medical diseases or psychiatric disorders Autism spectrum disorder group inclusion criteria: * Children with autism spectrum disorder (Diagnosis based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR)) Autism spectrum disorder group

Design outcomes

Primary

MeasureTime frameDescription
Oxidative stress markersFrom January 2020 to Jun 2021Total antioxidant status (μmol Trolox equivalent/ L)

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026