Acute Kidney Injury
Conditions
Brief summary
ICU patients are recruited after at least 5 days treatment with continuous renal replacement therapy. Blood samples are drawn at time of recruitment and then every 3-5 days until ceseation of renal replacement therapy. Samples will be analyzed for concentrations of trace elements, vitamins and amino acids. 10 adult ICU patients treated for two weeks without renal replacement therapy will be sampled at one time point to serve as controls.
Interventions
DIAGNOSTIC_TESTblood test
Blood samples are drawn every 3-5 days in the RRT group but only once in the control group
Sponsors
Karolinska University Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
CRRT group: * CRRT more than 5 days
Exclusion criteria
* N/A Inclusion criteria non-CRRT group \- ICU care 10-15 days without any dialysis treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of trace element | From enrollment to the end of treatment at 4 weeks | Measurments of trace elements and vitamins as compared to established reference values as well as non-CRRT controls |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Amino acids | From enrollment to the end of treatment at 4 weeks | Concentration of amino acids in plasma |
| Vitamins | At all measuring points | Water soluble vitamins, concentration in plasma. Compared to non-crrt controls and established references |
Contacts
Primary ContactJonathan Grip, MD, PhD
Backup ContactKristina Kilsand, Research nurse
Outcome results
None listed