The Proposed Study Aims to Investigate the Efficacy of Quercetin as an Adjunctive to Mechanical Debridement in Treatment of Periodontitis

Efficacy of Quercetin Loaded on Chitosan Nanoparticles Gel as an Adjunctive to Mechanical Debridement in Treatment of Periodontitis: Randomized Controlled Clinical Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06982248

Enrollment

Registered

2025-05-21

Start date

2024-08-15

Completion date

2025-06-01

Last updated

2025-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Pocket

Brief summary

the proposed study aims to investigate the effect of Quercetin in treatment of periodontitis patients

Detailed description

the proposed study aims to investigate the effect of Quercetin in treatment of periodontitis patients not having systemic diseases.the 2ry aim of study to estimate the neacular factor kabba B level in gingival crevicular fluids.

Interventions

DRUGNSP and chitosan nanoparticles gel loaded by quercetin

NSP and chitosan nanoparticles gel loaded by quercetin

DRUGNSP and chitosan nanoparticles gel

NSP and chitosan nanoparticles gel

PROCEDUREscaling and root planning

NSPT

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Intervention model description

Group 1: Periodontitis patients treated by NSPT and chitosan nanoparticles gel loaded by quercetin. Group 2: Periodontitis patients treated by NSPT and chitosan nanoparticles gel. Group 3: Periodontitis patients treated by NSPT only. Group 4: Periodontally healthy subjects.

Eligibility

Sex/Gender

ALL

Age

25 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

\- Patients of both sexes with an age ranging between 25 and 55 years will be included in the study. Patients diagnosed as having periodontitis based on clinical and radiographic examinations will be included

Exclusion criteria

* Insulin dependent diabetes * Thyroid disease * Patients with sensitivity to the medication used in the study * patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study will be excluded from the study. * Additionally, patients with systemic diseases, smokers, pregnant and lactating patients, and patients not compliant with oral hygiene procedures will also be excluded

Design outcomes

Primary

Measure	Time frame
assessment clinical attachment level by UNC 15 periodontal probe	12 weeks

Secondary

Measure	Time frame
assessment of the gingival crevicular levels of NF-κB by Elisa kit	12 weeks

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026