Cough
Conditions
Brief summary
The aim of this prospective randomized controlled double-blinded study is to compare the efficacy of dexmedetomidine, MgSO4 and lidocaine for cough suppression during general anesthetic emergence as regard number and severity.
Interventions
DRUGDexmedetomidine
Patients will receive 0.5 μg/kg dexmedetomidine in 10ml normal saline 10 min before the end of surgery.
DRUGMagnesium sulfate
Patients will receive 30 mg/kg IV magnesium sulfate 50% 10 min before the end of surgery.
DRUGLidocaine
Patients will receive lidocaine 1.5 mg/kg lidocaine 10 min before the end of surgery.
DRUGnormal saline
Patients will receive 10 ml normal saline 10 min before the end of surgery.
Sponsors
Al-Azhar University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Aged 21-60 years. * Both genders. * Body mass index \< 30 kg/ m2 * American Society of Anesthesiology (ASA) physical status I-II. * Mallampati score class I or II. * Patients undergoing surgery under general anesthesia.
Exclusion criteria
* Known allergy to study drugs. * History of psychiatric illness. * Patients with major organ diseases. * Pre-existing neurological deficits. * Body mass index \>30 kg/m2. * Active airway infection or history of tracheal and laryngeal surgery. * Lower esophageal sphincter incompetence (and reflux). * Increased intracranial and intraocular pressure. * Use of cough-inducing medications * Pregnant, and lactating women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cough suppression as regard number and severity. | at 0 and 10,20,30,40 minutes after endotracheal extubation. | Coughing severity will be classified using the 3 point scale described by Minogue et al.: 1 = mild, single cough, 2 = moderate (lasting for \<5 seconds) cough, and severe (lasting for \>5 seconds) cough. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative heart rate (HR). | at 15-minutes interval. | Changes in Intraoperative heart rate. change in heart rate per minute (HR/minute) will be all measured from the patient's arrival at the operating room to the end of surgery. |
| Intraoperative mean arterial blood pressure (MAP). | at 15-minutes interval. | Changes in Intraoperative mean arterial blood pressure (MAP). change in mean arterial blood pressure (MAP) in mmHg will be all measured from the patient's arrival at the operating room to the end of surgery. |
| Intraoperative arterial oxygen saturation (Spo2). | at 15-minutes interval. | Changes in Intraoperative arterial oxygen saturation (Spo2%). change in arterial oxygen saturation (Spo2%). be all measured from the patient's arrival at the operating room to the end of surgery. |
| Sedation score. | at 0,10,20,30, and 40 minutes after tracheal extubation. | Sedation score will be recorded using the Ramsay sedation score (Ramsay et al., 1974). |
Countries
Egypt
Contacts
Primary ContactMedhat H Allam, lecturer.MD
Backup ContactOsama H Ahmed, Professor.MD
Outcome results
None listed