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Comparison of Efficacy of Microneedling With Platelet Rich Plasma Vs Microneedling With Topical Insulin in the Treatment of Acne Scars

Comparison of Efficacy of Microneedling With Autologous Platelet-Rich Plasma vs Microneedling With Topical Insulin in the Treatment of Atrophic Acne Scars

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06978361
Enrollment
116
Registered
2025-05-18
Start date
2025-03-01
Completion date
2025-12-31
Last updated
2025-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-acne Atrophic Scars

Keywords

Post-acne atrophic scars, Microneedling with autologous Platelet- Rich Plasma, Microneedling with topical insulin

Brief summary

This study compares the outcome of two procedures for the treatment of atrophic acne scars.

Detailed description

Post acne scars develop due to severely inflamed and nodulocystic acne. Numerous methods exist for the treatment of post acne scars including lasers , microneedling and chemical peels etc . This study is to compare the efficacy two procedures.

Interventions

PROCEDUREMicroneedling with autologous Platelet Rich Plasma

Patients in group A will undergo Microneedling with autologous PRP

PROCEDUREMicroneedling with topical insulin

Patients in group B will undergo Microneedling with Topical insulin ( regular).

Sponsors

Khyber Teaching Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No

Inclusion criteria

Patients confirmed with post-acne atrophic scars . No prior treatment for scars in last 6 months. \-

Exclusion criteria

* Patient with active acne or other skin conditions (e.g eczema , psoriasis). Patients on oral or topical retinoids. Pregnant or lactating Mothers. Patients with recurrent herpes simplex infection. Previous Hx of keloids / hypertrophic scarring. Deranged blood glucose levels. Bleeding disorders

Design outcomes

Primary

MeasureTime frameDescription
Efficacy of treatment6 monthsEfficacy will be determined by using the Goodman and Baron's Scarring Grading System as Percentage of decrease in acne scar grade i.e calculated through subtracting post treatment grade from pre treatment grade and then multiplying it with 100 in both treatment groups .

Countries

Pakistan

Contacts

Primary ContactSoaiba Naeem, MBBS
soaiba91@gmail.com+923139493991

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026