Chorioretinal Changes, OCT Angiography, Primary Open Angle Glaucoma, Visual Field
Conditions
Brief summary
This study aimed to assess the correlation between visual field changes and optical coherence tomography (OCT) angiography changes of retinal nerve fiber layer in patients with primary open angle glaucoma.
Detailed description
Glaucoma is the leading cause of irreversible blindness worldwide. Since glaucomatous damage is preventable but irreversible, an early diagnosis and close follow-up of glaucoma patients are primordial. Optical coherence tomography angiography (OCTA) is a recently developed, noninvasive imaging modality that detects blood flow through the motion contrast generated by red blood cells. Currently, there are 2 groups of complementary exams used for the diagnosis and follow-up of glaucoma patients: structural (where OCT has a considerable role) and functional (visual field) optic nerve measurements, Both technologies have strengths and limitations. A new technology for diagnosis and follow-up that can avoid the limitations summarized above is lacking. OCTA seems to be a good candidate for such a role, OCT can detect the Doppler frequency shift of the backscattered light that provides information on blood flow.
Interventions
OTHERPOAG group
Patients had intraocular pressure (IOP)\>21 mmHg.
OTHERControl group
Patients without family history of primary open-angle glaucoma (POAG), IOP ˂21mm Hg.
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Primary open angle glaucoma patients.
Exclusion criteria
1. Hazy media. 2. Diabetic Retinopathy. 3. Uveitis. 4. Other Glaucomas * Acute congestive glaucoma * Secondary glaucomas
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peripapillary vessel density (PpVD) | 12 months post-procedure | Peripapillary vessel density (PpVD) was examined with swept-source OCT(DRI OCT Triton;Topcon Corporation,Tokyo,Japan) after pupillary dilatation , using an optic disc scan , peripapillary vessel density was derived from the images acquired with a 6 mm x6 mm mm field of view centered on the optic disc. PpVD measurements were calculated within the RNFL in a slab from the internal limiting membrane (ILM) to the RNFL posterior boundary. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pattern standard deviation (PSD) | 12 months post-procedure | Pattern standard deviation ( PSD) on Visual field test was performed with the Swedish Interactive Threshold Algorithm (SITA) Standard strategy program 24-2 of the octopus polar analysis which measures 24 degrees temporally and 30 degrees nasally and test 54 points. |
| Mean deviation (MD) | 12 months post-procedure | Mean deviation(MD) on Visual field test was performed with the Swedish Interactive Threshold Algorithm (SITA) Standard strategy program 24-2 of the octopus polar analysis which measures 24 degrees temporally and 30 degrees nasally and test 54 points. |
| The thickness of the peripapillary retinal nerve fiber layer(RNFL) | 12 months post-procedure | The thickness of the peripapillary retinal nerve fiber layer(RNFL) was obtained from a circle with a diameter of 3.4 mm centered on the optic disc. The RNFL thickness in 4 quadrants and 12 clock-hour were obtained by using the built-in automated segmentation algorism of the system. |
| Intraocular pressure (IOP) | 12 months post-procedure | Intraocular pressure (IOP) was recorded. |
Countries
Egypt
Outcome results
None listed