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Chronic Neck Pain and Central Sensizitation

Investigation of Central Sensitisation in Patients With Chronic Non-spesific Neck Pain

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06976398
Enrollment
83
Registered
2025-05-16
Start date
2025-05-08
Completion date
2025-09-15
Last updated
2026-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neck Pain

Brief summary

Chronic neck pain is one of the musculoskeletal pain problems that can cause chronic disability. It is emphasised that individuals with chronic neck pain have difficulty during different activities in their daily lives, and that this problem is a very common health problem that can lead to disability. In the case of chronic neck pain, changes in the pain threshold cause central sensitisation and individuals become more sensitive to pain stimuli. This situation can affect the processing of proprioceptive information and lead to deterioration in proprioceptive perception. This situation leads to perceptual problems in body and neck awareness. Therefore, examining the relationship between the relevant parameters is important in the rehabilitation process. In this context, the aim of the study is to examine the relationship between body awareness and pain, central sensitisation, disability and proprioception in patients with chronic non-specific neck pain.

Detailed description

Chronic neck pain is a common pain problem related to the musculoskeletal system and can lead to permanent (chronic) disability over time. In approximately 50-85% of individuals with neck pain, complaints do not completely improve despite treatment, causing the pain to become chronic. Individuals with chronic neck pain have difficulty performing various activities in their daily lives, and this negatively affects their quality of life. Proprioceptive feedback in the neck region, that is, sensory information that allows the body to perceive its position in space, is very important for proper control of head and neck movements. However, chronic pain can lead to a condition called central sensitization. In this case, the individual's pain threshold decreases and they become more sensitive to stimuli that would normally not cause pain. This increased sensitivity can make it difficult for the brain to process proprioceptive information correctly, which can lead to impairments in body and neck awareness. Therefore, investigating the relationship between body awareness and pain level, central sensitization, disability status and proprioception in individuals with chronic non-specific neck pain is of great importance in terms of developing an effective rehabilitation program.

Interventions

None listed

Sponsors

Karabuk University
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

* Being between the ages of 18-65 * Being diagnosed with chronic non-specific neck pain by a doctor * Being willing to participate in the study

Exclusion criteria

* Having psychological disorders, mental disorders, cancer and severe depression * Having a history of traumatic injury * Having a history of primary or metastatic spinal malignancy, spinal fracture * Having a neurological disease (Hemiplegia, Multiple Sclerosis, Parkinson's, etc.) * Having been diagnosed with advanced osteoporosis * Having a history of surgical intervention or acute infection in the cervical region

Design outcomes

Primary

MeasureTime frameDescription
Central sensitizationBaselineIt will be evaluated with the "Central Sensitization Scale". The scale is scored between 0-100 and 40 points and above is recorded as sensitive.
Pain severityBaselinePain intensity will be assessed with the Numerical Pain Scale. It is scored between 0-10 and the higher the score, the greater the pain intensity.
Pain thresholdBaselinePain threshold will be assessed with an algometer. An increase in the applied pressure indicates a higher pain threshold.
Neck disabilityBaselineNeck disability will be evaluated with the index. It varies between 0-50 points and the higher the score, the higher the disability.
ProprioceptionBaselineProprioception will be recorded as the degree of deviation with the CROM device. As the degree of deviation increases, proprioception worsens.
Body awarenessBaselineBody Awareness Questionnaire (BAF) will be used. It varies between 18-126 points and as the score decreases, awareness decreases.
Neck awarenessBaselineIt will be assessed with the Fremantle Neck Awareness Questionnaire. It varies between 0-36 and as the score increases, awareness decreases.

Countries

Turkey (Türkiye)

Contacts

STUDY_DIRECTORMusa Gunes, PhD

Karabuk University

PRINCIPAL_INVESTIGATORMelek Turan

Karabuk University

PRINCIPAL_INVESTIGATORDuygu Çataloluk

Karabuk University

PRINCIPAL_INVESTIGATORAydın Sinan Apaydın, PhD

Karabuk University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 23, 2026