Blood Flow Restriction Training, Glomerular Filtration Rate, Quality of Life, Hemodialysis
Conditions
Brief summary
this study was done to investigate the effect of intradialytic blood flow restriction training on functional capacity, estimated glomerular filtration rate and health related Quality of life in patients on Hemodialysis
Detailed description
Chronic kidney disease affects 10% to 15% of the population and is characterized by a progressive decline in glomerular filtration rate. The disease can lead to frailty, muscle mass wasting, and sarcopenia, affecting functional mobility and quality-of-life measures. The increased protein catabolism in Chronic kidney disease is partly due to inflammatory status, nutrient loss during dialysis, and musculoskeletal system changes. Assessment of muscle functionality can provide additional diagnostic and prognostic information for clinical outcomes, quality of life, and mortality rates. Exercise training with blood flow restriction is a potential method for clinical musculoskeletal rehabilitation, potentially improving strength, physical function, blood pressure control, glucose homeostasis, autonomic function, renal deterioration, dialysis adequacy, and antioxidant defenses.
Interventions
Exercises include shoulder flexion, shoulder abduction, leg extension, and hand grip. Start with 1-3 sets of 12 reps at 30% of 1-repetition maximum, increasing by 10% according to patient endurance. Cycling is a 30-minute chair or bedside cycle ergometer exercise 2 time/weak for 2 consecutive months
OTHERblood flow restriction training
Patients received the same conventional exercise program, which included isometric, aerobic, and resisted exercise individualized for every patient with blood flow restriction by 50% of limb occlusion pressure. Training will be conducted for 2 time/weak for 2 consecutive month
Sponsors
Beni-Suef University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
40 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
All patients were 1. Both sex aged from forty to sixty years 2. Stable chronic hemodialysis patient (\< 3 months) 3. Participants will be deemed medically eligible by their treating physician before participation in the present study 4. Free from any other disease could interfere with exercise
Exclusion criteria
1. Hemodynamic instability during hemodialysis over the last month 2. Neurodegenerative diseases 3. Autoimmune diseases (i.e., lupus erythematosus) 4. Surgery within the past 3 months 5. Severe arrhythmia, angina or cerebrovascular disease 6. Unstable on dialysis 7. Any musculoskeletal problem interfere with exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| assessment of change of estimated glomerular filtration rate | at baseline and after 8 weeks | Estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration Creatinine Equation (2021) as recommended by the National Kidney Foundation to assess renal function and detect deterioration. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| assessment of change of Limb Occlusion Pressure | at baseline and after 8 weeks | Limb occlusion pressure was measured using a vascular Doppler ultrasound in combination with a blood flow restriction device to determine individualized occlusion thresholds. |
| assessment of change of Glucose Homeostasis | at baseline and after 8 weeks | Glucose regulation was assessed through glycated hemoglobin (HbA1c) levels, reflecting average blood glucose over the previous 2-3 months |
| assessment of change of upper limb Muscle Strength | at baseline and after 8 weeks | Upper limb strength was measured using a handgrip dynamometer. |
| assessment of change of lower limb Muscle Strength | at baseline and after 8 weeks | lower limb strength was assessed using the One-Repetition Maximum (1RM) test to determine maximum voluntary strength |
Countries
Egypt
Outcome results
None listed