Accelerated Orthodontics With Alveolar Decortication Plus CGF Injection

Impact of Alveolar Decortication Combined With CGF Injection on Acceleration of Maxillary Canine Retraction-A Randomized Clinical Trial

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06975358

Enrollment

Registered

2025-05-16

Start date

2025-05-20

Completion date

2025-11-30

Last updated

2025-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Accelerate Tooth Movement

Brief summary

The aim of the present study is to evaluate alveolar bone decortication combined with CGF Injection on tooth movement acceleration

Interventions

PROCEDUREAlveolar decortication plus CGF injection

Experimental sides will receive CGF injection (70 units) disto-buccal and disto-palatal to the maxillary canine after performing decortication. After administration of local anesthesia, two-line flap will be performed from the mesial surface of the maxillary second premolar to the distal surface of the maxillary canine Mucoperiosteal flap will be reflected in the buccal side. Two millimeters of marginal crestal bone will be held intact and using a high-speed drill and a round carbide bur (1mm diameter) under copious saline irrigation, the cortical wall will be penetrated to reach marrow spaces. Multiple perforations (10 holes for standardization) in the cortical bone will be created. The surgical site will then rinsed, and the flap will be repositioned and sutured.

PROCEDUREcanine retraction without acceleration

in the control side, the maxillary canine will be retracted without any acceleration procedure

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

16 Years to 22 Years

Healthy volunteers

Inclusion criteria

1. Age of the patients ranged from 16: 22 years old. 2. Malocclusion that requires extraction of the maxillary first premolar and canine retraction (e.g. class I bimaxillary dentoalveolar protrusion and class II div 1 malocclusion). 3. Maximum anchorage needed for the maxillary arch as a part of the orthodontic treatment plan. 4. Good oral hygiene and periodontal condition.

Exclusion criteria

1. Medically compromised patients. 2. Severe crowding in the maxillary arch. 3. Chronic intake of NSAIDs or any medication that interfere with OTM. 4. Previous orthodontic treatment.

Design outcomes

Primary

Measure	Time frame
rate of canine retraction	4 months

Countries

Egypt

Contacts

Primary ContactSafa B Alawy, PhD

safa_basyouny@dent.tanta.edu.eg0201009088252

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026