PET/MRI/EEG Imaging Study in Epilepsy

Investigation of Interictal Metabolic and Electrophysiologic Changes in Epilepsy Through Trimodal Neuroimaging

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06974305

Enrollment

Registered

2025-05-15

Start date

2023-09-21

Completion date

2026-12-31

Last updated

2026-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Keywords

Functional PET, FDG-PET, Functional MRI, EEG, Epilepsy, Neuroimaging, Multimodal imaging

Brief summary

This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.

Interventions

RADIATIONFDG-PET/fMRI/EEG imaging

Subject will undergo simultaneous EEG, fMRI, and FDG-PET imaging. This includes the use of a standard injected radioactive marker used in PET imaging.

Study design

Observational model

CASE_CONTROL

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age 18 or older Additional Inclusion Criteria for Subjects with Epilepsy: * Diagnosed with epilepsy with abnormal interictal EEG

Exclusion criteria

* Contraindications to PET, MRI, or EEG imaging * History of severe brain disease such as stroke and head trauma * History of brain surgery * History of type I or II diabetes mellitus * Fasting plasma glucose level \>200 mg/dL * Employed under direct supervision of the PI conducting the research Additional

Design outcomes

Primary

Measure	Time frame	Description
Image analysis	Image analysis to be performed after imaging sessions are complete.	There are no interventions in this study and thus no outcome measures. Primary goal of the study will be achieved with image analysis on the PET/MRI/EEG data.

Countries

United States

Contacts

CONTACTMagdelena S Allen, BA

mallen27@mgh.harvard.edu617-724-9232

PRINCIPAL_INVESTIGATORCiprian Catana, MD, PhD

Massachusetts General Hospital

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 24, 2026