Prevalence and Description of FIRE (Food Induced Immediate Response of the Esophagus) in the Pediatric Population With Eosinophilic Esophagitis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06972147

Acronym

FIREO

Enrollment

Registered

2025-05-14

Start date

2025-07-01

Completion date

2026-08-01

Last updated

2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eosinophilic Esophagitis

Brief summary

A new clinical entity of eosinophilic esophagitis, Food Induced Immediate Response of the Esophagus or FIRE, has been described since 2020. Diagnostic criteria are not clearly established. Specific questioning is necessary for differential diagnosis, such as the oro-pharyngeal syndrome notably described in pollinics, or a mechanical blockage strictly speaking linked to esophagitis. The aim is to obtain epidemiological data on this entity.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Years to 17 Years

Healthy volunteers

Inclusion criteria

* Patients over 6 and under 18 years of age at the time of inclusion * Follow-up in the allergology unit of Angers University Hospital for eosinophilic esophagitis

Exclusion criteria

* Patients or legal representative with severe communication or language comprehension difficulties * Patients or legal representatives objecting to study participation

Design outcomes

Primary

Measure	Time frame	Description
diagnosis of FIRE syndrome	day 1	symptoms such as pain, pressure, choking or narrowing, in the oesophagus or retrosternum, within 10 minutes of ingestion, lasting a maximum of 120 minutes, when a specific food is ingested

Countries

France

Contacts

CONTACTAnne HOPPE, MD

anne.hoppe@chu-angers.fr241353637

PRINCIPAL_INVESTIGATORAnne HOPPE

University Hospital of Angers

Outcome results