Cervical Radiculopathy
Conditions
Brief summary
This project will study patients with cervical radiculopathy. We will evaluate the combined diagnostic and prognostic value of magnetic resonance neurography (MRN), electrodiagnostic (EDX) studies, and historical and physical clinical elements. Specifically, this project will explore whether these data individually or in combination correlate with response to procedural and non-procedural treatment.
Interventions
DIAGNOSTIC_TESTMagnetic resonance neurography
Patients will undergo a cervical MRI with specialized magnetic resonance neurography sequences to evaluate the extraforaminal cervical nerve roots.
Sponsors
Hospital for Special Surgery, New York
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients presenting with symptoms compatible with acute or subacute unilateral (one-sided) cervical radiculopathy and signs of clinical weakness * 18-60 years old at the time of evaluation * Symptom onset of 2 to 12 weeks leading up to baseline visit * Diagnosis of unilateral cervical radiculopathy, with or without spinal cord compression, based on signs and symptoms, physical exam and supported by MRI findings of radiculopathy (as evidenced by foraminal stenosis/narrowing) based on standard-of-care cervical spine MRI * Patients who have undergone or have planned electrodiagnostic testing at HSS prior to surgery
Exclusion criteria
* Prior cervical surgery or instrumentation * Those who have had a prior episode of cervical radiculopathy * History of peripheral neuropathy or another acute or chronic neurodegenerative condition * History of stroke, cerebellar disease, or central nervous system disease * Contraindications to undergoing a standard MRI examination (e.g., pregnancy) * Patients presenting with bilateral cervical radiculopathy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of abnormalities on nerve (MRN) imaging | Baseline | Presence of abnormalities on cervical MRN imaging that correspond to clinical findings of cervical radiculopathy. This includes abnormalities in extraforaminal cervical nerve root intraneural T2 signal and DTI values. |
| Relationship between abnormalities on imaging and electrodiagnostic assessment | Baseline | The relationship between any abnormalities identified on nerve imaging (cervical MRN) and electrodiagnostic findings will be assessed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Numeric rating scale (NRS) pain | Baseline, 3 months, 6 months, 12 months | Current NRS pain will be assessed on 0-10 scales (10=worst pain). |
| Neck Disability Index (NDI) | Baseline, 3 months, 6 months, 12 months | NDI is scored on a 0-100% scale, with 100% representing complete disability. |
Countries
United States
Contacts
CONTACTJ. Levi Chazen, MD
CONTACTCarlo Milani, MD
Outcome results
None listed