Non-Occlusive Mesenteric Ischemia
Conditions
Brief summary
This prospective multicenter observational study, conducted between June , 2022, and April, 2023, is a preplanned analysis of the AMESI study titled 'Demographics, diagnosis, management, and outcomes of non-occlusive mesenteric ischemia,' aiming primarily to describe the demographic profile, clinical presentation, and laboratory findings of patients with non-occlusive mesenteric ischemia (NOMI), and secondarily to identify independent risk factors as well as diagnostic approaches, management strategies, and outcomes-including in-hospital, 90-day, and one-year results.
Interventions
OTHERNo intervention
No intervention, this is an observational study on patients with suspected acute mesenteric ischemia
Sponsors
University of Tartu
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
All at least 18-year-old patients with acute mesenteric ischemia or patients suspected of acute mesenteric ischemia that was not confirmed * Patients with arterial occlusive AMI * Patients with non-occlusive mesenteric ischemia * Patients with venous occlusive AMI * Patients with unclear mechanism of AMI * Patients with suspected but not confirmed AMI
Exclusion criteria
* Patients with other specific form of AMI (e.g dissection) * Confirmed strangulating bowel obstruction * Individuals under 18 years of age. * Consent declined by patient or next of kin * Chronic mesenteric ischaemia without an acute event
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Arterial Blood pH in Patients with Non-Occlusive Mesenteric Ischemia | Baseline | Arterial pH level. Normal range is 7.35-7.45. Lower values indicate acidosis. |
| Demographic profile | Baseline | One of the primary objectives is to describe the baseline demographic profile of patients with non-occlusive mesenteric ischemia. The demographic data will include the following information: 1. Gender (Male or Female) 2. Age (in years) 3. BMI (calculated from body weight in kilograms and height in centimeters) |
| SOFA score | Baseline | Sequential Organ Failure Assessment (SOFA) score. Range: 0-24. Higher scores indicate more severe organ dysfunction. |
| Serum Lactate Levels in Patients with Non-Occlusive Mesenteric Ischemia | Baseline | Serum lactate level measured in mmol/L. Higher values indicate worse tissue perfusion. |
| Baseline APACHE II Score | Baseline | Acute Physiology and Chronic Health Evaluation II (APACHE II) score. Range: 0-71. Higher scores indicate more severe disease and higher predicted mortality. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Management | Baseline | Rate of surgical, conservative, endovascular or palliative management |
| 30-day survival | 30 days after admission | 30-day Survival of patients with non-occlusive mesenteric ischemia |
| 1-year survival | 1 year | 1-year survival of patients with non-occlusive mesenteric ischemia |
| Rate of Patients Diagnosed with Non-Occlusive Mesenteric Ischemia by CT, Endoscopy, or Angiography | Baseline | Percentage of participants diagnosed with non-occlusive mesenteric ischemia (NOMI) using computed tomography (CT), endoscopy, or angiography. |
Countries
Estonia
Outcome results
None listed